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Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

bioRxiv

Dec 3, 2014

Chia-Yen ChenAlkes L. Price

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Abstract

Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations...read more

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Disease Predictive Factor
Cross Validation
Simulation
Single Nucleotide Polymorphism
Population Group
Genome-Wide Association Study
EAF2 gene
European American
Gene Therapy
MERRF SYNDROME, 8344A-G; G8344; MTTK*MERRF8344 (allelic variant)
5
2
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  • Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

    bioRxiv

    Dec 3, 2014

    Chia-Yen ChenAlkes L. Price

    PMID: 990012005

    DOI: 10.1101/012005

    Abstract

    Polygenic prediction using genome-wide SNPs can provide high prediction accuracy for complex traits. Here, we investigate the question of how to account for genetic ancestry when conducting polygenic prediction. We show that the accuracy of polygenic prediction in structured populations...read more

    Mentioned in this Paper

    Disease Predictive Factor
    Cross Validation
    Simulation
    Single Nucleotide Polymorphism
    Population Group
    5
    2

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