Exploitation of novel gum Prunus cerasoides as mucoadhesive beads for a controlled-release drug delivery

International Journal of Biological Macromolecules
T Veenus SeelanK Ruckmani

Abstract

The present study deals with the formulation of pH-sensitive mucoadhesive beads using natural gum isolated from Prunus cerasoides (PC) in combination with sodium alginate (SA) for the controlled release of diclofenac sodium (DS). PC and SA composite (PC-SA), DS loaded SA (DS-SA) and DS loaded PC-SA (DS-PC-SA) beads were prepared by ionotropic gelation method. The absence of interaction between DS and PC-SA was shown by FTIR, DSC and TGA analyses. The optimized DS-PC-SA formulation exhibited mucoadhesive property and the controlled release of DS was achieved 68% in 12h. The in vitro release kinetics follows zero order with anomalous diffusion mechanism. Therefore, the formulated mucoadhesive beads with the novel gum are preferable for the controlled release of DS by prolonging the residence time of the drug in the gastrointestinal tract, overcoming the problems associated with the immediate release dosage forms of DS.

References

Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·M E PalomoP Frutos
Sep 26, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Oya SanliNuran Işiklan
Oct 10, 2012·Carbohydrate Polymers·Grazielle Arantes SoaresRaul C Evangelista
Jan 22, 2013·Colloids and Surfaces. B, Biointerfaces·Pravat Ranjan GuruRajendra Kumar Sahu
Mar 21, 2013·International Journal of Biological Macromolecules·Raghavendra V KulkarniAkram A Naikawadi
Mar 30, 2013·International Journal of Biological Macromolecules·Subham BanerjeePronobesh Chattopadhyay
May 1, 2013·International Journal of Biological Macromolecules·Amit Kumar Nayak, Dilipkumar Pal
May 31, 2014·International Journal of Biological Macromolecules·C MalsawmtluangiLalduhsanga Pachuau

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Citations

Aug 11, 2016·International Journal of Biological Macromolecules·Veenus Seelan TRuckmani Kandasamy
Dec 29, 2020·Carbohydrate Polymers·Khadijeh SoleimaniHadi Samadian

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