Exploitation of redox discrepancy in leukemia cells by a reactive oxygen species nanoscavenger for inducing cytotoxicity in imatinib resistant cells

Journal of Colloid and Interface Science
Sarbari Acharya, Sanjeeb K Sahoo

Abstract

Chronic myeloid leukemia (CML) has been the hub of exhilarating progress in cancer therapy with the advent of imatinib mesylate. However, therapeutic selectivity and drug resistance are two major issues in imatinib based leukemia therapy prompting development of strategies to surmount imatinib resistance for effective CML therapy. Growing evidences advocate that, cancer cells exhibit augmented intrinsic reactive oxygen species (ROS), due to oncogenic stimulation, amplified metabolic activity, and mitochondrial dysfunction. Since ROS activates multidrug resistant proteins in CML cells, we hypothesized that an herbal molecule having ROS scavenging property may therefore enhance imatinib induced cell death in drug resistant cells by counteracting ROS mediated drug resistance. In the present study, we document to explore an approach to simultaneously deliver two drugs (imatinib, an anticancer drug for CML therapy and curcumin a ROS scavenger) using poly (lactide-co-glycolide) (PLGA) nanoparticles for drug resistant CML cells. Such a combinational approach will help to enhance the therapeutic efficacy of imatinib by utilizing ROS scavenging properties of curcumin in imatinib resistant cell line thereby sensitizing them to chemothera...Continue Reading

References

Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jayanth PanyamVinod Labhasetwar
May 24, 2005·Cancer Biology & Therapy·Yuying MeiJianwen Liu
Oct 11, 2005·Critical Reviews in Oncology/hematology·Christoph Walz, Martin Sattler
Feb 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·C E ChwieralskiF Bühling
Oct 29, 2008·Oncogene·P Boya, G Kroemer
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hae Yun NamSeo Young Jeong
Dec 8, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ranjita Misra, Sanjeeb K Sahoo
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dragana Milojkovic, Jane Apperley
Sep 7, 2011·Current Drug Metabolism·Murali Mohan YallapuSubhash Chand Chauhan
Jan 31, 2012·Biochemical Pharmacology·Che-Ming Jack Hu, Liangfang Zhang
Jun 2, 2012·Drug Discovery Today·Priyambada ParhiSanjeeb Kumar Sahoo
Sep 14, 2012·Expert Opinion on Drug Delivery·Chandana MohantySanjeeb K Sahoo
Mar 19, 2013·Frontiers in Pharmacology·Hiba Zahreddine, Katherine L B Borden
Apr 24, 2013·Therapeutic Advances in Hematology·Pavan Kumar BhamidipatiElias Jabbour
Mar 26, 2014·South Asian Journal of Cancer·Shweta Bansal
Sep 23, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Manasi DasSanjeeb K Sahoo

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Citations

Jan 1, 2019·Cell Biology International·Fernanda Saldanha SoaresAna Paula de Souza Votto
Apr 22, 2020·Biomaterials Science·Lifen HuangChun Chen
Mar 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Geetanjali AryaSanjeeb Kumar Sahoo

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