Exploiting Bacteriophage Proteomes: The Hidden Biotechnological Potential

Trends in Biotechnology
Sílvio B SantosJoana Azeredo

Abstract

Bacteriophages encode many distinct proteins for the successful infection of a bacterial host. Each protein plays a specific role in the phage replication cycle, from host recognition, through takeover of the host machinery, and up to cell lysis for progeny release. As the roles of these proteins are being revealed, more biotechnological applications can be anticipated. Phage-encoded proteins are now being explored for the control, detection, and typing of bacteria; as vehicles for drug delivery; and for vaccine development. In this review, we discuss how engineering approaches can be used to improve the natural properties of these proteins and set forth the most innovative applications that demonstrate the unlimited biotechnological potential held by phage-encoded proteins.

Citations

Jan 27, 2019·Molecular & Cellular Proteomics : MCP·Marie-Laurence LemaySylvain Moineau
Oct 4, 2019·The ISME Journal·Lisa FazzinoWilliam R Harcombe
Jul 14, 2020·Biotechnology and Bioengineering·Sílvio B SantosCarla M Carvalho
Jan 11, 2020·Frontiers in Microbiology·Jing BaiLizhen Huang
Aug 14, 2019·Viruses·Sílvio B Santos, Joana Azeredo
Apr 1, 2019·Molecular & Cellular Proteomics : MCP·Marie-Laurence LemaySylvain Moineau
Jun 18, 2020·The Plant Pathology Journal·Nguyen Trung Vu, Chang-Sik Oh
May 27, 2021·Biotechnology and Bioengineering·Alexandra P CunhaCarla M Carvalho
Jun 26, 2021·Infectious Diseases and Therapy·Bilal AslamZulqarnain Baloch
Aug 17, 2021·Plastic and Reconstructive Surgery·Chandan K SenGayle M Gordillo
Dec 5, 2019·ACS Applied Materials & Interfaces·Tam-Triet Ngo-DucElaine D Haberer
Oct 8, 2021·ACS Infectious Diseases·Catarina L NogueiraCarla M Carvalho

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