Exploiting cellular-developmental evolution as the scientific basis for preventive medicine.

Medical Hypotheses
J S Torday, Virender K Rehan

Abstract

In the post-genomic era, we must make maximal use of this technological advancement to broaden our perspective on biology and medicine. Our understanding of the evolutionary process is undermined by looking at it retrospectively, perpetuating a descriptive rather than a mechanistic approach. The reintroduction of developmental biologic principles into evolutionary studies, or evo-devo, allows us to apply embryologic cell-molecular biologic principles to the mechanisms of phylogeny, obviating the artificial space and time barriers between ontogeny and phylogeny. This perspective allows us to consider the continuum between the proximate and ultimate causes of speciation, which was unthinkable when looked at from the descriptive perspective. Using a cell-cell interactive 'middle-out' approach, we have gained insight to the evolution of the lung from the swim bladder of fish based on gene regulatory networks that generate both lung ontogeny and phylogeny, i.e. decreased alveolar size, decreased alveolar wall thickness, and increased alveolar wall strength. Vertical integration of cell-cell interactions predicts the adaptivity and maladaptivity of the lung, leading to novel insights for chronic lung disease. Since we have employed p...Continue Reading

References

Dec 1, 1978·The Anatomical Record·C Vaccaro, J S Brody
Jun 10, 1977·Science·F Jacob
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M YamamotoM A Thiede
Mar 1, 1992·Respiration Physiology·E R WeibelH Hoppeler
Dec 29, 1967·Science·A S Romer
Aug 7, 1970·Science·J A ClementsH J Trahan
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·E HuB M Spiegelman
Jan 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·S N Wickramasinghe
Apr 15, 1994·Annals of Internal Medicine·C S Bryan
Jun 6, 1998·Journal of Biological Rhythms·L Weibel, G Brandenberger
Sep 28, 1998·The American Journal of the Medical Sciences·J S TordayL P Rubin
Nov 10, 1998·Critical Reviews in Eukaryotic Gene Expression·B Lanske, H M Kronenberg
Dec 8, 1998·Journal of Applied Physiology·C G TankersleyP Smith
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·M C BruceR J Cross
Aug 17, 1999·The Journal of Clinical Investigation·B LanskeH M Kronenberg
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·M I RamirezM C Williams
Mar 8, 2000·Mechanisms of Development·D WarburtonW V Cardoso
Sep 15, 2000·Biological Chemistry·S KaeslerU Rüther
May 5, 2001·Genome Research·F S Collins
Jun 1, 2001·Pediatric Research·J S TordayV Rehan
Jul 18, 2001·Journal of Applied Physiology·J Sanchez-EstebanL P Rubin
Feb 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S TordayL P Rubin
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S Torday, V K Rehan
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·C J SchultzJ S Torday
Aug 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·F DemayoJ S Torday
Nov 1, 2002·Molecular Genetics and Metabolism·László G BorosVirender K Rehan
Feb 21, 2003·American Journal of Respiratory Cell and Molecular Biology·Donald Massaro, Gloria DeCarlo Massaro
Feb 26, 2003·Archives of Physical Medicine and Rehabilitation·Paul Miskovitz
Mar 6, 2003·Mechanisms of Ageing and Development·Leroy Hood
Jun 10, 2003·Cell Biochemistry and Biophysics·V Rehan, J Torday
Nov 10, 1961·Science·E MAYR
Jan 27, 2004·American Journal of Respiratory and Critical Care Medicine·Scott T Weiss, Stephanie Shore
Feb 10, 2004·American Journal of Respiratory and Critical Care Medicine·Peter T Macklem
Feb 24, 2004·Annual Review of Physiology·John M Shannon, Brian A Hyatt
Mar 6, 2004·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·J S Torday
Apr 13, 2004·Bioscience Reports·Sydney Brenner

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Citations

Apr 16, 2009·Physiological Genomics·J S Torday, V K Rehan
Jul 14, 2012·PPAR Research·Virender K Rehan, John S Torday
May 3, 2016·Biology·John S Torday
Jun 2, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gulenay Gencosmanoglu TurkmenDilek Uygur
Jun 9, 2021·Progress in Biophysics and Molecular Biology·John S Torday

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