Exploiting Copper Redox for (19)F Magnetic Resonance-Based Detection of Cellular Hypoxia

Journal of the American Chemical Society
Da XieEmily L Que

Abstract

We report a pair of fluorinated, redox-active copper complexes for potential use as (19)F MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched (19)F NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F3 resulted in a selective detection of (19)F signal in cells grown under hypoxic conditions.

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Citations

Feb 9, 2017·Chemical Communications : Chem Comm·Olatz MichelenaMónica Carril
Nov 15, 2016·Chemical Communications : Chem Comm·Meng YuEmily L Que
Aug 17, 2018·Chemical Communications : Chem Comm·Chang GuoLeyu Wang
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Sep 12, 2020·Chemical Communications : Chem Comm·Zan LiZhilin Wang
Jul 2, 2020·Organic & Biomolecular Chemistry·Jie GaoXianfeng Gu
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Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Monica Carril
Oct 12, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·José S EnriquezEmily L Que
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Sep 20, 2019·Bioconjugate Chemistry·Mi Hyeon ChoYongdoo Choi
Aug 7, 2018·Chemical Reviews·Zhenchuang XuYanchuan Zhao
Oct 12, 2021·Analytical Chemistry·Chang GuoLeyu Wang

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