Exploiting graft-versus-tumour responses using donor leukocyte infusions

Best Practice & Research. Clinical Haematology
K S Peggs, S Mackinnon

Abstract

Allogeneic stem cell transplantation (SCT) has become the treatment of choice for some patients with haematological malignancies, allowing dose escalation of chemo-radiotherapy beyond the limits imposed by bone marrow toxicity. However, it is now apparent that dose escalation alone does not eradicate the malignancy in many cases and that an associated immune-mediated graft-versus-malignancy effect may be equally important. Its presence is supported by the following observations: anecdotal reports that patients with relapsed leukaemia following SCT may re-enter remission after withdrawal of immunosuppressive drugs; the lower risk of relapse associated with the development of graft-versus-host-disease (GVHD); and an increased risk of relapse in patients receiving syngeneic transplants or T-cell depleted allogeneic marrow grafts. More directly compelling evidence has been provided by the efficacy of donor lymphocyte infusions, particularly for relapsed chronic-phase CML. Issues that remain to be resolved include the precise nature of the effector cells and their target antigens, the best strategies for separating graft-versus-malignancy from GVHD, the role of adjuvant chemotherapy/cytokines, and the role of non-myeloablative trans...Continue Reading

References

May 10, 1979·The New England Journal of Medicine·P L WeidenR Storb
Jun 18, 1981·The New England Journal of Medicine·P L WeidenUNKNOWN Seattle Marrow Transplant Team
Apr 15, 1994·Annals of Internal Medicine·R P GaleM M Bortin
Jan 13, 1994·The New England Journal of Medicine·D L PorterJ H Antin
Mar 23, 1996·Lancet·L F VerdonckE J Petersen
Aug 3, 1996·Lancet·J AschanG Gahrton
Nov 14, 1998·Current Opinion in Hematology·E H WarrenS R Riddell
Nov 14, 1998·Current Opinion in Hematology·I F KhouriR Champlin
Jun 3, 1999·The New England Journal of Medicine·E C GuinanJ G Gribben
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D BonnetS R Riddell
Aug 28, 1999·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·D L PorterJ H Antin
Mar 21, 2000·Bone Marrow Transplantation·A M CarellaR Storb
May 4, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A B RickinsonN E Annels
Aug 5, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·E OrsiniJ Ritz
Sep 28, 2000·Current Opinion in Immunology·S Slavin
Jan 10, 2001·Bone Marrow Transplantation·M SalamaR H Collins

❮ Previous
Next ❯

Citations

Jun 21, 2011·Advances in Hematology·S E Richardson, C McNamara
Sep 14, 2004·Leukemia & Lymphoma·Karl S Peggs
Aug 20, 2008·British Journal of Haematology·Karl S PeggsAnna Sureda
May 22, 2010·Cornea·Arnaud C WestenengAniki Rothova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

Current Opinion in Hematology
K S Peggs, S Mackinnon
Expert Opinion on Biological Therapy
V Bhatia, D L Porter
Best Practice & Research. Clinical Haematology
Robert J Soiffer
© 2022 Meta ULC. All rights reserved