Feb 9, 2011

Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls

Immunology and Cell Biology
Daniëlle HorstE J Wiertz

Abstract

Herpesviruses stand out for their capacity to establish lifelong infections of immunocompetent hosts, generally without causing overt symptoms. Herpesviruses are equipped with sophisticated immune evasion strategies, allowing these viruses to persist for life despite the presence of a strong antiviral immune response. Although viral evasion tactics appear to target virtually any stage of the innate and adaptive host immune response, detailed knowledge is now available on the molecular mechanisms underlying herpesvirus obstruction of MHC class I-restricted antigen presentation to T cells. This opens the way for clinical application. Here, we review and discuss recent efforts to exploit human herpesvirus MHC class I evasion strategies for the rational design of novel strategies for vaccine development, cancer treatment, transplant protection and gene therapy.

  • References116
  • Citations14

Citations

Mentioned in this Paper

Human Class I Antigens
Immune Response
Thymic Group Viruses
Immune Evasion
T-Lymphocyte
Simplexvirus
Herpesviridae Infections
Vaccination
Obstruction
Genes, MHC Class I

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