Exploiting human memory B cell heterogeneity for improved vaccine efficacy.

Frontiers in Immunology
Noel T PauliPatrick C Wilson

Abstract

The major goal in vaccination is establishment of long-term, prophylactic humoral memory to a pathogen. Two major components to long-lived humoral memory are plasma cells for the production of specific immunoglobulin and memory B cells that survey for their specific antigen in the periphery for later affinity maturation, proliferation, and differentiation. The study of human B cell memory has been aided by the discovery of a general marker for B cell memory, expression of CD27; however, new data suggests the existence of CD27⁻ memory B cells as well. These recently described non-canonical memory populations have increasingly pointed to the heterogeneity of the memory compartment. The novel B memory subsets in humans appear to have unique origins, localization, and functions compared to what was considered to be a "classical" memory B cell. In this article, we review the known B cell memory subsets, the establishment of B cell memory in vaccination and infection, and how understanding these newly described subsets can inform vaccine design and disease treatment.

Citations

Sep 14, 2013·Science·David Tarlinton, Kim Good-Jacobson
Mar 22, 2014·Science Translational Medicine·Nicole L YatesGeorgia D Tomaras
Jan 28, 2014·Journal of Immunological Methods·J J TaylorM Pravetoni
Jan 10, 2018·Frontiers in Immunology·Alexis SennepinMorgane Bomsel
Apr 2, 2015·Immunology·Birte S Steiniger
Jun 6, 2020·American Journal of Respiratory and Critical Care Medicine·Swati PhalkePhilippa Marrack
Jun 8, 2017·Annals of Clinical and Translational Neurology·Markus C KowarikJeffrey L Bennett
Mar 30, 2021·Immunological Investigations·Wei Luo, Qian Yin
Jun 28, 2021·Hematology/oncology Clinics of North America·Anita Ng, Nicholas Chiorazzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.