Exploiting immunometabolism and T cell function for solid organ transplantation.

Cellular Immunology
Jennifer B Allocco, Maria-Luisa Alegre

Abstract

Cellular metabolism is central to T cell function and proliferation, with most of the research to date focusing on cancer and autoimmunity. Cellular metabolism is associated with a host of physiological phenomena, from epigenetic changes, to cellular function and fate. For the purpose of this review, we will discuss the metabolism of T cells relating to their differentiation and function. We will cover a variety of metabolic processes, ranging from glycolysis to amino acid metabolism. Understanding how T cell metabolism informs T cell function may be useful to understand alloimmune responses and design novel therapies to improve graft outcome.

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Luis F HernandezMidhat H Abdulreda

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