Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of protein-coding genes in non-canonical reading frames and translation of allegedly non-coding sequences. In general, cryptic MAPs are coded by relatively short open reading frames whose translation can be regulated at the level of initiation, elongation or termination. In contrast to conventional MAPs, the processing of cryptic MAPs is frequently proteasome independent. The existence of cryptic MAPs derived from allegedly non-coding regions enlarges the scope of CD8 T cell immunosurveillance from a mere ~2% to as much as ~75% of the human genome. Considering that 99% of cancer-specific mutations are located in those allegedly non-coding regions, cryptic MAPs could furthermore represent a particularly rich source of tumor-specific antigens. However, extensive proteogenomic analyses will be required to determine the breath as well as the temporal and spatial plasticity of the cryptic MAP repertoire in normal and neoplastic cells.
RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes
Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study
A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma
Identification of a unique antigen peptide pRL1 on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene
Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen
A peptide recognized by human cytolytic T lymphocytes on HLA-A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene
Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
Initiation codon scanthrough versus termination codon readthrough demonstrates strong potential for major histocompatibility complex class I-restricted cryptic epitope expression
A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes
Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage
Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1
Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism
A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription
Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa)
An alternative open reading frame of the human macrophage colony-stimulating factor gene is independently translated and codes for an antigenic peptide of 14 amino acids recognized by tumor-infiltrating CD8 T lymphocytes
Identification and characterisation of a developmentally regulated mammalian gene that utilises -1 programmed ribosomal frameshifting
+1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10
Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy
Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation
A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia
Cytolytic CD8+ T cells directed against a cryptic epitope derived from a retroviral alternative reading frame confer disease protection
Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues
Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers
PRFdb: a database of computationally predicted eukaryotic programmed -1 ribosomal frameshift signals
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses
Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules.
Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast
Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences
Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes
Statistical analysis of readthrough levels for nonsense mutations in mammalian cells reveals a major determinant of response to gentamicin
Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress
Frameshift-derived neoantigens constitute immunotherapeutic targets for patients with microsatellite-instable haematological malignancies: frameshift peptides for treating MSI+ blood cancers
Direct detection of alternative open reading frames translation products in human significantly expands the proteome
Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway
The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences
Cryptic MHC class I-binding peptides are revealed by aminoglycoside-induced stop codon read-through into the 3' UTR
PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism
New insights into the incorporation of natural suppressor tRNAs at stop codons in Saccharomyces cerevisiae
Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?
Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation
Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs
CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins
IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
ChimeRScope: a novel alignment-free algorithm for fusion transcript prediction using paired-end RNA-Seq data
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth
Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients
Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
STING Receptor Agonists
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Chronic Fatigue Syndrome
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Applications of Molecular Barcoding
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