Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Tony W NgSteven A Porcelli

Abstract

The continuing emergence of viral pathogens and their rapid spread into heavily populated areas around the world underscore the urgency for development of highly effective vaccines to generate protective antiviral Ab responses. Many established and newly emerging viral pathogens, including HIV and Ebola viruses, are most prevalent in regions of the world in which Mycobacterium tuberculosis infection remains endemic and vaccination at birth with M. bovis bacille Calmette-Guérin (BCG) is widely used. We have investigated the potential for using CD4+ T cells arising in response to BCG as a source of help for driving Ab responses against viral vaccines. To test this approach, we designed vaccines comprised of protein immunogens fused to an immunodominant CD4+ T cell epitope of the secreted Ag 85B protein of BCG. Proof-of-concept experiments showed that the presence of BCG-specific Th cells in previously BCG-vaccinated mice had a dose-sparing effect for subsequent vaccination with fusion proteins containing the Ag 85B epitope and consistently induced isotype switching to the IgG2c subclass. Studies using an Ebola virus glycoprotein fused to the Ag 85B epitope showed that prior BCG vaccination promoted high-affinity IgG1 responses th...Continue Reading

References

Feb 12, 2000·Clinical and Experimental Immunology·D Goldblatt
Dec 6, 2000·The Journal of Experimental Medicine·P SchaerliB Moser
Mar 13, 2001·Annual Review of Immunology·J L Flynn, J Chan
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A CherukuriS K Pierce
Jan 31, 2004·Seminars in Immunology·Stephan R Krutzik, Robert L Modlin
Sep 27, 2006·Acta Crystallographica. Section D, Biological Crystallography·A Radu AricescuE Yvonne Jones
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea J WolfJoel D Ernst
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hidde L Ploegh
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreia P SoaresWillem A Hanekom
Nov 28, 2009·Vaccine·Maeve K LalorHazel M Dockrell
Mar 30, 2011·PLoS Medicine·Alice ZwerlingMadhukar Pai
Dec 23, 2011·Vaccine·Manjunatha M VenkataswamySteven A Porcelli
Oct 6, 2012·AIDS Research and Human Retroviruses·Nicos KarasavvasUNKNOWN MOPH TAVEG Collaboration
Jan 8, 2013·The Journal of Infectious Diseases·Andreia P SoaresWillem A Hanekom
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Michael E Pichichero
Aug 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·David C Parker
May 6, 2014·Frontiers in Immunology·Teresa PrezzemoloNadia Caccamo
Oct 24, 2014·Annual Review of Medicine·Jerome H KimNelson L Michael
Feb 14, 2015·Nature Reviews. Immunology·Shane Crotty
Jul 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuseppe LofanoSylvie Bertholet
Jul 30, 2015·BioMed Research International·Joaquim C V D Van-DunemRicardo Arraes de Alencar Ximenes
Nov 20, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sadegh EivaziMaryam Yasemi
Jan 25, 2017·Infection and Immunity·Alison J JohnsonSteven A Porcelli
Feb 24, 2017·Current Opinion in HIV and AIDS·Justin PollaraGenevieve G Fouda

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