Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR-B1

European Journal of Immunology
Marcos VasquezPedro Berraondo

Abstract

Scavenger receptors (SRs) are structurally heterogeneous cell surface receptors characterized by their capacity to remove extraneous or modified self-macromolecules from circulation, thus avoiding the accumulation of noxious agents in the extracellular space. This scavenging activity makes SRs important molecules for host defense and homeostasis. In turn, SRs keep the activation of the steady-state immune response in check, and participate as co-receptors in the priming of the effector immune responses when the macromolecules are associated with a threat that might compromise host homeostasis. Therefore, SRs built up sophisticated sensor mechanisms controlling the immune system, which may be exploited to develop novel drugs for cancer immunotherapy. In this review, we focus on the regulation of the anti-tumor immune response by two paradigmatic SRs: the lymphocyte receptor CD5 and the more broadly distributed scavenger receptor class B type 1 (SR-B1). Cancer immunity can be boosted by blockade of SRs working as immune checkpoint inhibitors (CD5) and/or by proper engagement of SRs working as innate danger receptor (SR-B1). Thus, these receptors illustrate both the complexity of targeting SRs in cancer immunotherapy and also the ...Continue Reading

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Jan 4, 2018·Oncotarget·Inês T SimõesFrancisco Lozano
Dec 1, 2019·International Journal of Environmental Research and Public Health·Cheng-Hsueh LeeBo-Ying Bao
Jun 15, 2019·Current Pharmaceutical Design·Eugeny Yu Gusev, Natalia V Zotova
Sep 24, 2020·International Journal of Molecular Sciences·Adam WłodarskiAgnieszka Śliwińska
Sep 24, 2021·Seminars in Liver Disease·Daniel A PattenShishir Shetty

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