Exploiting the apoptotic process for management of HIV: are we there yet?

Apoptosis : an International Journal on Programmed Cell Death
Y Yang, J D Ashwell

Abstract

CD4+ T cells die in individuals infected with HIV, either as a result of direct HIV infection or as uninfected "innocent bystanders". Possible mechanisms for bystander killing include generation of viral products such as Tat or gp120 and expression of death receptor ligands, such as FasL, that engage functional death receptors on uninfected cells. This review covers the sometimes conflicting in vitro and ex vivo studies that address these possible mechanisms of HIV-associated cell death. It is an intriguing possibility that manipulation of cell death processes, to decrease bystander death or increase death of infected cells, in patients infected with HIV might provide a useful adjunct to antiretroviral therapy.

Citations

Apr 12, 2003·AIDS Research and Human Retroviruses·Jean-Charles GrivelLeonid B Margolis
Feb 12, 2004·Scandinavian Journal of Immunology·E KrambovitisD A Spandidos
Oct 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cheryl TwuMilan Fiala

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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