Exploiting the bioengineering versatility of lactobionic acid in targeted nanosystems and biomaterials

Journal of Controlled Release : Official Journal of the Controlled Release Society
Saúl Alonso

Abstract

Lactobionic acid (LBA) has rapidly emerged as a strategic functionalization molecule in the development of nanoparticle-based platforms and biomaterials with promising therapeutic applications. Exploiting the multi-functionality of LBA has enabled to expand the drug loading, release and selective cellular uptake capacity of hepatoma-targeting chemotherapy and nanoparticle-based theranostic systems. The high liver-specificity displayed by LBA-conjugated dendrimers, micelles and nanoparticles has indeed reinforced the great potential of LBA in fine-tuning the surface engineering of promising drug carriers to combat hepatocellular carcinoma. Additionally, its cytocompatibility, selectivity and functionality confer unique properties to design synthetically engineered matrices with enhanced liver-specificity for liver tissue engineering applications. Notably, the biospecific identification and biochemical cross-linking specificity found with the asialoglycoprotein receptor (ASGPR) have converted LBA into the perfect cell-targeting ligand for strengthening the recognition between novel designed nanocarriers and hepatocytes at cellular level. The present review overviews the latest advances in the galactosylation of target-specific na...Continue Reading

Citations

Apr 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu LuKaiyong Cai
Nov 11, 2020·Drug Development Research·Selvaraj KunjiappanPanneerselvam Theivendren
Feb 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Francesca PersanoRawil Fakhrullin
Jul 12, 2021·International Journal of Biological Macromolecules·Xiaoqing LiuRupei Tang

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