Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions

Nanoscale
Johanna SimonVolker Mailänder

Abstract

Formation of the biomolecular corona ultimately determines the successful application of nanoparticles in vivo. Adsorption of biomolecules such as proteins is an inevitable process that takes place instantaneously upon contact with physiological fluid (e.g. blood). Therefore, strategies are needed to control this process in order to improve the properties of the nanoparticles and to allow targeted drug delivery. Here, we show that the design of the protein corona by a pre-formed protein corona with tailored properties enables targeted cellular interactions. Nanoparticles were pre-coated with immunoglobulin depleted plasma to create and design a protein corona that reduces cellular uptake by immune cells. It was proven that a pre-formed protein corona remains stable even after nanoparticles were re-introduced to plasma. This opens up the great potential to exploit protein corona formation, which will significantly influence the development of novel nanomaterials.

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Citations

Jun 28, 2019·Lab on a Chip·Luca DigiacomoGiulio Caracciolo
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Methods Mentioned

BETA
dynamic
isothermal titration
dynamic light scattering
transmission electron microscopy
flow cytometry
Assay
isothermal titration calorimetry
protein Assay
FCS

Software Mentioned

FCS Express
Excel
DeNovo
MassLynx
Progenesis GI

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