Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines

Frontiers in Immunology
Lien VandenberkStefaan W Van Gool

Abstract

Cancer immunotherapy is currently the hottest topic in the oncology field, owing predominantly to the discovery of immune checkpoint blockers. These promising antibodies and their attractive combinatorial features have initiated the revival of other effective immunotherapies, such as dendritic cell (DC) vaccinations. Although DC-based immunotherapy can induce objective clinical and immunological responses in several tumor types, the immunogenic potential of this monotherapy is still considered suboptimal. Hence, focus should be directed on potentiating its immunogenicity by making step-by-step protocol innovations to obtain next-generation Th1-driving DC vaccines. We review some of the latest developments in the DC vaccination field, with a special emphasis on strategies that are applied to obtain a highly immunogenic tumor cell cargo to load and to activate the DCs. To this end, we discuss the effects of three immunogenic treatment modalities (ultraviolet light, oxidizing treatments, and heat shock) and five potent inducers of immunogenic cell death [radiotherapy, shikonin, high-hydrostatic pressure, oncolytic viruses, and (hypericin-based) photodynamic therapy] on DC biology and their application in DC-based immunotherapy in ...Continue Reading

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Citations

Jul 1, 2017·International Journal of Molecular Sciences·Laura MühleisenChristina Janko
Mar 31, 2018·Cancer Immunology, Immunotherapy : CII·Daniel Rojas-SepúlvedaFlavio Salazar-Onfray
Sep 17, 2016·F1000Research·Alan E BilslandT R Jeffry Evans
Jan 23, 2019·Advanced Healthcare Materials·Eun Sook LeeJae Hyung Park
Mar 18, 2020·Pharmaceutics·María Julia LambertiJessica Dal Col
May 2, 2019·Frontiers in Cell and Developmental Biology·Alfonso Serrano-Del ValleIsabel Marzo
Apr 16, 2020·Frontiers in Cell and Developmental Biology·Hui ZhangYou-Wen He
Mar 31, 2018·Frontiers in Immunology·Maarten VerstevenEva Lion
Feb 6, 2018·Oncoimmunology·Claudia MaletzkiMichael Linnebacher
Dec 31, 2020·Cancers·Stefaan W Van GoolWilfried Stuecker

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT00700167
NCT01456104
NCT01189383
NCT00890032
NCT00846456
NCT01171469
NCT01567202
NCT01287468

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