Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles

Bioorganic & Medicinal Chemistry Letters
Rémy C LemoineDavid M Rotstein

Abstract

The introduction of N-substituted pyrazoles in a new series of CCR5 antagonists was shown to substantially increase antiviral activity.

Citations

Oct 30, 2016·Expert Opinion on Investigational Drugs·Michelle B KimLawrence J Wilson
Jun 17, 2015·Journal of Medicinal Chemistry·Marianne Lucas-HouraniYves L Janin

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