Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine

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Shuang WangGuanghui Ma

Abstract

Therapeutic vaccines possess particular advantages and show promising potential to combat burdening diseases, such as acquired immunodeficiency syndrome, hepatitis, and even cancers. An efficient therapeutic vaccine would strengthen the immune system and eventually eliminate target cells through cytotoxic T lymphocytes (CTLs). Unfortunately, insufficient efficacy in triggering such an adaptive immune response is a problem that remains unsolved. To achieve efficient cellular immunity, antigen-presenting cells must capture and further cross-present disease-associated antigens to CD8 T cells via major histocompatibility complex I molecules. Here, a biomimetic strategy is developed to fabricate hierarchical ovalbumin@CaCO3 nanoparticles (OVA@NP, ≈500 nm) under the templating effect of antigen OVA. Taking advantage of the unique physicochemical properties of crystalline vaterite, cluster structure, and high loading, OVA@NP can efficiently ferry cargo antigen to dendritic cells and blast lysosomes for antigen escape to the cytoplasm. In addition, the first evidence that the physical stress from generated CO2 induces autophagy through the LC3/Beclin 1 pathways is presented. These outcomes cooperatively promote antigen cross-presentati...Continue Reading

References

Apr 8, 1993·Biochimica Et Biophysica Acta·D V Zhelev, D Needham
Mar 22, 2002·Nature Reviews. Immunology·W R Heath, F R Carbone
Sep 27, 2005·Immunological Reviews·Kenneth L Rock, Lianjun Shen
Sep 20, 2007·Nature Immunology·Peter E Jensen
Dec 11, 2007·Nature Biotechnology·Rino Rappuoli
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ming Lee LinAndrew M Lew
Nov 1, 2008·Chemical Reviews·Matthew B DickersonRajesh R Naik
Nov 5, 2008·Journal of the American Chemical Society·Wei WeiZhe-Yu Shen
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nadine van MontfoortFerry Ossendorp
Jun 6, 2009·The Journal of Physical Chemistry. B·Xiaoqiang WangJian R Lu
Apr 8, 2010·The Journal of Physical Chemistry. B·Xiaoqiang WangJian R Lu
Nov 10, 2010·Chemical Society Reviews·Stefaan De KokerBruno G De Geest
Feb 4, 2011·International Journal of Nanomedicine·Jian ChenYuhong Xu
Sep 13, 2011·Nature Nanotechnology·Nam-Hyuk ChoSeung-Yong Seong
Jan 24, 2012·Nature Materials·Ashley L St JohnSoman N Abraham
May 30, 2012·Advanced Materials·James J MoonDarrell J Irvine
Sep 15, 2012·Advanced Materials·Xuan Qi Li, Hua Chun Zeng
Feb 18, 2014·Nature·Haipeng LiuDarrell J Irvine
Apr 5, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Salka KellerPatrick S Stayton
Dec 30, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qin ZengXun Sun
Mar 6, 2015·Nature·Heidi Ledford

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Citations

Sep 15, 2020·Pediatric Research·Dheeraj SoniDavid J Dowling
Mar 2, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Benke LiRuikang Tang
Mar 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qian LiDongming Xing
May 23, 2021·Advanced Healthcare Materials·Hang WuGuangxi Zhai
Aug 3, 2021·Biomedical Materials·Jiansheng LinZonghua Liu
Sep 19, 2020·Accounts of Chemical Research·Yufei XiaGuanghui Ma
May 13, 2019·ACS Biomaterials Science & Engineering·Ning WangXigang Leng

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