Exploration of baseline and early changes in neurocognitive characteristics as predictors of treatment response to bupropion, sertraline, and placebo in the EMBARC clinical trial

Psychological Medicine
Yuen-Siang AngDiego Pizzagalli

Abstract

Treatment for major depressive disorder (MDD) is imprecise and often involves trial-and-error to determine the most effective approach. To facilitate optimal treatment selection and inform timely adjustment, the current study investigated whether neurocognitive variables could predict an antidepressant response in a treatment-specific manner. In the two-stage Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) trial, outpatients with non-psychotic recurrent MDD were first randomized to an 8-week course of sertraline selective serotonin reuptake inhibitor or placebo. Behavioral measures of reward responsiveness, cognitive control, verbal fluency, psychomotor, and cognitive processing speeds were collected at baseline and week 1. Treatment responders then continued on another 8-week course of the same medication, whereas non-responders to sertraline or placebo were crossed-over under double-blinded conditions to bupropion noradrenaline/dopamine reuptake inhibitor or sertraline, respectively. Hamilton Rating for Depression scores were also assessed at baseline, weeks 8, and 16. Greater improvements in psychomotor and cognitive processing speeds within the first week, as well as better pr...Continue Reading

References

Oct 1, 1996·Archives of General Psychiatry·W KatonE Walker
Aug 15, 2000·Journal of Affective Disorders·J J DunkinS Rosenberg-Thompson
Jan 5, 2002·The American Journal of Psychiatry·Andrew F LeuchterMichelle Abrams
May 3, 2002·The American Journal of Psychiatry·Helen S MaybergPaul A Jerabek
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Nov 5, 2003·The American Journal of Psychiatry·Balu Kalayam, George S Alexopoulos
Feb 12, 2005·Biological Psychiatry·Diego A PizzagalliJames P O'Shea
Jan 5, 2006·The American Journal of Psychiatry·Madhukar H TrivediUNKNOWN STAR*D Study Team
Jan 5, 2006·The American Journal of Psychiatry·Bonnie P TaylorFrederic M Quitkin
Jun 26, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Joel R SneedHarold A Sackeim
Jul 17, 2008·Journal of Neural Transmission·Marianne GorlynJ John Mann
Oct 17, 2008·American Journal of Public Health·Astrid C J NooyensW M Monique Verschuren
Jan 24, 2009·Current Opinion in Pharmacology·Kent C BerridgeJ Wayne Aldridge
Mar 3, 2009·Journal of Affective Disorders·Richard TranterIan M Anderson
Jan 7, 2010·JAMA : the Journal of the American Medical Association·Jay C FournierJan Fawcett
Oct 14, 2011·Drug and Alcohol Dependence·Timothy C DurazzoSara Jo Nixon
Dec 12, 2012·Biological Psychiatry·Elske VriezeStephan Claes
Mar 2, 2013·Nature Reviews. Drug Discovery·Paul EnckWinfried Rief
Apr 8, 2014·International Journal of Geriatric Psychiatry·Paulo R ShiromaKelvin O Lim
Jun 26, 2014·The International Journal of Neuropsychopharmacology·Paulo R ShiromaKelvin O Lim
Jul 12, 2014·Journal of Affective Disorders·Gerard E BruderPatrick J McGrath
Nov 7, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James W MurroughDan V Iosifescu
Dec 31, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amit EtkinLeanne M Williams
Mar 6, 2015·The Journal of Clinical Psychiatry·Paul E GreenbergRonald C Kessler
Mar 13, 2015·Annals of the New York Academy of Sciences·Alan F Schatzberg
Mar 24, 2016·The Pharmacogenomics Journal·R D HolmesJ L Kennedy
Apr 4, 2016·Journal of Psychiatric Research·Madhukar H TrivediMyrna M Weissman
Oct 27, 2016·Depression and Anxiety·Marie-Laure Cléry-Melin, Philip Gorwood
Sep 14, 2018·Frontiers in Psychiatry·Samantha J GrovesRichard J Porter

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