Exploration of Energy Metabolism in the Mouse Using Indirect Calorimetry: Measurement of Daily Energy Expenditure (DEE) and Basal Metabolic Rate (BMR)

Current Protocols in Mouse Biology
Carola W MeyerMatthias H Tschöp

Abstract

Current comprehensive mouse metabolic phenotyping involves studying energy balance in cohorts of mice via indirect calorimetry, which determines heat release from changes in respiratory air composition. Here, we describe the measurement of daily energy expenditure (DEE) and basal metabolic rate (BMR) in mice. These well-defined metabolic descriptors serve as meaningful first-line read-outs for metabolic phenotyping and should be reported when exploring energy expenditure in mice. For further guidance, the issue of appropriate sample sizes and the frequency of sampling of metabolic measurements is also discussed.

References

May 1, 1978·The Proceedings of the Nutrition Society·K L Blaxter
Dec 1, 1986·The Journal of Clinical Investigation·E RavussinC Bogardus
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·G P WebbM E Jakobson
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·P C EvenA Pele
May 16, 1997·Science·J Himms-Hagen
Jun 9, 2000·Annual Review of Physiology·A J Hulbert, P L Else
Oct 23, 2002·ILAR Journal·Ralph B DellRajasekhar Ramakrishnan
Oct 16, 2004·Obesity Research·Carola W E MeyerGerhard Heldmaier
Jan 28, 2005·Physiological and Biochemical Zoology : PBZ·Aneta KsiazekIwona B Lapo
Jan 28, 2005·Physiological and Biochemical Zoology : PBZ·John R SpeakmanMaria S Johnson
Mar 16, 2005·The Journal of Experimental Biology·Glenn E Walsberg, Ty C M Hoffman
Jun 28, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J R S ArchJ R Speakman
Jul 4, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Stephen M Secor
Nov 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Matthew D BrussMarc K Hellerstein
Dec 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kenneth A LongoBrad J Geddes
Apr 24, 2010·Diabetes·Karl J KaiyalaMichael W Schwartz
Apr 30, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Karl J Kaiyala, Douglas S Ramsay
Jun 19, 2010·Nutrition·David C Frankenfield
Sep 10, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carola W MeyerMartin Klingenspor
Dec 8, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J R B Lighton, L G Halsey
Dec 24, 2010·The Journal of Experimental Biology·Barbara Cannon, Jan Nedergaard
Mar 8, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juen Guo, Kevin D Hall
Jun 28, 2011·Integrative and Comparative Biology·Murray M Humphries, Vincent Careau
Dec 30, 2011·Nature Methods·Matthias H TschöpEric Ravussin
Jun 22, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick C Even, Nachiket A Nadkarni
Mar 23, 2013·Disease Models & Mechanisms·John R SpeakmanLobke Vaanholt
May 4, 2013·Frontiers in Physiology·Jan B van KlinkenKo Willems van Dijk
Aug 22, 2013·American Journal of Physiology. Endocrinology and Metabolism·Colin M L Burnett, Justin L Grobe
Jan 1, 2012·Molecular Metabolism·John R Speakman, Jaap Keijer
Dec 18, 2013·Journal of Lipid Research·Kirsten GrimpoGerhard Heldmaier
Jun 20, 2014·Molecular Metabolism·Karl J Kaiyala
Sep 10, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jan RozmanMartin Hrabě de Angelis
Jun 5, 2015·Molecular Metabolism·Gustavo Abreu-VieiraMarc L Reitman

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Citations

Jan 12, 2017·European Journal of Clinical Nutrition·J R B Lighton
Nov 6, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Adel DerghalLourdes Mounien
Feb 12, 2020·American Journal of Physiology. Endocrinology and Metabolism·Felicia CastriotaMichele A La Merrill
Jun 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bochra TourkiGanesh V Halade
Sep 2, 2016·Current Protocols in Mouse Biology·Lee MoirRoger D Cox
Aug 22, 2017·Frontiers in Physiology·Carola W MeyerAndrej A Romanovsky

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