Exploration of genetics commonness between bladder cancer and breast cancer based on a silcio analysis on disease subtypes

Technology and Health Care : Official Journal of the European Society for Engineering and Medicine
Wenbin XuLin Hua

Abstract

Muscle-invasive bladder cancers (MIBCs) are heterogeneous cancers and can be grouped into basal-like and luminal subtypes that are highly reminiscent of those found in breast cancer. Like basal-like breast cancers, basal-like MIBCs are associated with advanced stage and metastatic disease. However, the biological and clinical significance of molecular subtypes of MIBCs remain unclear. Therefore, we implemented a serious of bioinformatics methods to explore genetic similarities between bladder and breast cancers. In the current study, by the application of multiple levels data analysis including random forest analysis, PPI and transcription factor regulation network construction, Gene Ontology (GO) and KEGG pathway enrichment analysis, we explored the genetics commonness between MIBC and breast cancers from the molecular heterogeneity based on the disease subtypes. Our study identified some basal-related and luminal-related genes shared by two cancers. These studies can help shed light on the potential relationships between MIBC and breast cancer as a whole.

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Methods Mentioned

BETA
biosensor

Software Mentioned

Random
randomForest
Limma
Cytoscape
DAVID
CancerSubtypes
Array Tools
R
BRB

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