Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), a Japanese traditional herbal medicine

Metabolomics : Official Journal of the Metabolomic Society
Masahito UjiMasato Nagino

Abstract

In patients with obstructive jaundice, biliary drainage sometimes fails to result in improvement. A pharmaceutical-grade choleretic herbal medicine, Inchinkoto (ICKT), has been proposed to exert auxiliary effects on biliary drainage; however, its effects are variable among patients. The aim of this study is to explore serum biomarkers that are associated with pharmaceutical efficacy of ICKT. Obstructive jaundice patients who underwent external biliary decompression were enrolled (n = 37). ICKT was given orally 3 times a day at daily dose of 7.5 g. Serum and bile samples were collected before, 3 h after, and 24 h after ICKT administration. The concentrations of total bilirubin, direct bilirubin, and total bile acid in bile specimens were measured. Metabolites in serum samples were comprehensively profiled using LC-MS/MS and GC-MS/MS. Pharmacokinetic analysis of major ICKT components was also performed. ICKT administration significantly decreased serum ALT and increased bile volume after 24 h. The serum concentrations of ICKT components were not well correlated with the efficacy of ICKT. However, the ratio of 2-hydroxyisobutyric acid to arachidonic acid and the ratio of glutaric acid to niacinamide, exhibited good performance as ...Continue Reading

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Citations

Dec 3, 2021·Metabolomics : Official Journal of the Metabolomic Society·Hiromasa YamashitaYukihiro Yokoyama

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Methods Mentioned

BETA
PCA

Software Mentioned

Cytoscape
Labsolutions LCMS
Shimadzu GCMSsolution
GraphPad Prism
Excel
GCMSsolution
SIMCA
Labsolutions Insight
MetaboAnalyst

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