Exploration of the Exact Prognostic Significance of Lymphatic Metastasis in Jejunoileal Neuroendocrine Tumors

Annals of Surgical Oncology
Luohai ChenJie Chen

Abstract

How to evaluate the prognostic significance of lymphatic metastasis in patients with small bowel (jejunoileal) neuroendocrine tumors (SBNETs) is still not conclusive. Data for patients with SBNETs, but without distant metastasis, were retrieved from the Surveillance, Epidemiology, and End Results database. Recursive partitioning analysis (RPA) was used for classification development by combining examined lymph nodes (ELNs) and lymph node ratio (LNR). Overall, 1925 patient records were retrieved. Patients with N0 and N1 disease (based on the definition of the European Neuroendocrine Tumor Society [ENETS] staging classification) did not have different OS (p = 0.7867), nor did patients with N0, N1 (< 12 positive nodes), and N2 (≥ 12 positive nodes) disease based on the definition of American Joint Committee on Cancer (AJCC) 8th edition staging classification (p = 0.5276). However, Cox regression analysis indicated that both ELNs (hazard ratio [HR] 0.968, 95% confidence interval [CI] 0.949-0.987; p = 0.0013) and LNR (HR 2.288, 95% CI 1.122-3.682; p = 0.0006) were prognostic factors. Using RPA, we combined ELNs and LNR, and patients were reclassified into three groups (group 1: ELNs ≥ 12, any LNR; group 2: ELNs < 12, LNR < 0.35; gro...Continue Reading

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Citations

Aug 10, 2018·World Journal of Gastroenterology : WJG·Kosmas Daskalakis, Apostolos V Tsolakis
Jan 3, 2019·Annals of Surgical Oncology·Luohai ChenJie Chen
Jul 28, 2020·Journal of Clinical Medicine·Sophie DeguelteReza Kianmanesh
Feb 2, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Epameinondas DogeasMathew M Augustine
Aug 31, 2020·Current Treatment Options in Oncology·Alexandra Gangi, Daniel A Anaya
Apr 17, 2021·Journal of Cancer Research and Clinical Oncology·Kun DengJianhong Zuo
Jun 11, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jie-Bin XieXiao-Ting Wu

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