Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts

Experimental Lung Research
Keiko HiyamaMasahiko Nishiyama

Abstract

Regulation mechanism of lung fibroblast proliferation remains unknown. To elucidate the key molecules in it, the authors here established mortal and immortal nontransformed lung fibroblast cell line/strains with elongated life span by telomerase reverse transcriptase gene transfection. Comparing the expression profiles of them, 51 genes were explored to be the candidates responsible for regulation of cellular proliferation of lung fibroblasts. This set of fibrobrast strains of same origin with different proliferative capacities may become useful model cells for research on lung fibroblast growth regulation and the candidate genes explored in this study may provide biomarkers or therapeutic targets of pulmonary fibrosis.

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Citations

Jun 4, 2011·Endocrine-related Cancer·Yuriko MoriStephen J Meltzer
Feb 6, 2010·The American Journal of Pathology·Michala de NeergaardLone Rønnov-Jessen

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