Exploration of the unusual two-step volume phase transition of the poly(N-vinylcaprolactam-co-hydroxyethyl methacrylate) hydrogel

Physical Chemistry Chemical Physics : PCCP
Gehong SuTao Zhou

Abstract

It is important to investigate the phase transition mechanism of stimuli-sensitive hydrogels due to its great guiding significance for the application of stimuli-sensitive hydrogels in biomedical applications. In this work, the novel thermo-sensitive poly(N-vinylcaprolactam-co-hydroxyethyl methacrylate) (PVCL-co-HEMA) hydrogel was successfully synthesized via free radical polymerization, and then temperature-dependent FTIR spectra combined with the newly developed scaling moving-window two-dimensional (scaling-MW2D) correlation spectroscopy and generalized two-dimensional correlation analysis were utilized to investigate its volume phase transition (VPT) mechanism upon heating. Conventional 1D FTIR spectra and Boltzmann fitting results revealed that the PVCL-co-HEMA hydrogel exhibited a distinct VPT behavior from the neat PVCL hydrogel due to the incorporation of PHEMA. The essential reason is that some water molecules were still confined in the PVCL-co-HEMA network after phase transition at high temperature, rather than continuously being expelled out of the gel with the increase of temperature. Scaling-MW2D spectra revealed that the phase transition of the PVCL-co-HEMA hydrogel could be divided into two steps (I and II), and ...Continue Reading

References

Jun 6, 2002·Drug Discovery Today·Piyush GuptaSanjay Garg
Jul 21, 2006·The Journal of Physical Chemistry. B·Maria-Cristina PopescuGh Singurel
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leda Klouda, Antonios G Mikos
Mar 8, 2008·Journal of Biomaterials Science. Polymer Edition·L Kris KostanskiCarlos D M Filipe
Jul 24, 2008·Chemical Society Reviews·Lin Yu, Jiandong Ding
Jul 30, 2010·The Journal of Physical Chemistry. B·Shengtong SunPeiyi Wu
Sep 9, 2011·The Journal of Physical Chemistry. B·Shengtong Sun, Peiyi Wu
Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ana Guzman-AranguezJesús Pintor
Mar 19, 2014·ACS Applied Materials & Interfaces·Sina NaficyGordon G Wallace
Jan 25, 2016·Gels·Kummara Madhusudana RaoChang-Sik Ha

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Citations

Jan 28, 2020·Soft Matter·Sanjoy MondalArun K Nandi

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Methods Mentioned

BETA
2D correlation spectroscopy
NMR

Software Mentioned

2DCS

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