Explorative analysis of the gene expression profile during liver regeneration of mouse: a microarray-based study

Artificial Cells, Nanomedicine, and Biotechnology
Li YinQianfeng Xia

Abstract

The liver is an amazing organ due to its powerful regenerative capacity. Although many studies on liver regeneration have been documented, the detailed mechanisms remain unclear. Two-third partial hepatectomy (PH) in rodents plays a crucial role in the study of liver regeneration. In this study, the time series data of gene expression during liver regeneration in mouse were analyzed using the gene set numbered GSE6998 in GEO. A variety of bioinformatics methods, including masigPro, Weighted Gene Co-expression Network Analysis (WGCNA), spatial analysis of functional enrichment (SAFE) and ingenuity canonical pathway analysis (IPA) were used to identify and compare the significantly changed pathways, potential upstream regulators and key genes during liver regeneration. Our study showed that liver regeneration in the mouse is a coordinated process, which cell-cycle-related progress are at the centre of the interaction network involved in liver regeneration. Several candidate upstream regulators including PPARA, NFE2L2, MAD1 and CNR1 and some key genes such as Cdk1, Plk1, Cdc20, Aurka, Racgap1, Cenpa, Rrm1, Rrm2 were identified. In conclusion, these findings could contribute to revealing the molecular mechanism of liver regeneratio...Continue Reading

References

Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuPeter G Schultz
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven P AndersonJ Christopher Corton
Jan 15, 2003·BMC Bioinformatics·Gary D Bader, Christopher W V Hogue
Jan 18, 2007·The Journal of Biological Chemistry·Hasan H OtuSeth J Karp
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Yoshio YamamotoNaofumi Nagasue
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
May 14, 2009·Molecular Cancer Research : MCR·Chao-Chin LiTing-Fen Tsai
Jul 15, 2009·Methods in Molecular Biology·Sarah KillcoyneJohn Boyle
Dec 19, 2009·The American Journal of Pathology·George K Michalopoulos
Jan 23, 2010·Science·Michael CostanzoCharles Boone
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Changku Jia
Jun 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vered GazitDavid A Rudnick
Jul 5, 2013·PloS One·Hui-Xin LiuYu-Jui Yvonne Wan
Dec 7, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ulrike A KöhlerSabine Werner
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Jun 5, 2014·Bioinformatics·María José NuedaAna Conesa
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Nov 18, 2014·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Weiwei WeiUta Dahmen
Dec 19, 2014·BMC Systems Biology·Chia-Hao ChinChung-Yen Lin
Dec 20, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuhong ZouGuoli Dai
Apr 19, 2015·Computational Biology and Chemistry·Dongbin BiKejia Ding
Jan 19, 2016·Cancer Medicine·Jan BornscheinPeter Malfertheiner
May 31, 2016·Cell Systems·Anastasia Baryshnikova
Jun 30, 2016·Nature Reviews. Gastroenterology & Hepatology·Stuart J Forbes, Philip N Newsome
Aug 11, 2016·F1000Research·Malcolm R Alison, Wey-Ran Lin
Mar 18, 2017·The Journal of Biological Chemistry·Yoshihiro SatoKazuhiko Igarashi

Related Concepts

Metazoa
Liver Regeneration
Cdna Microarrays
MRNA Differential Display
Mouse, Swiss
Cell Cycle
Gene Expression
Genes
Hepatectomy
Liver

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