Exploratory analyses assessing the impact of early tumour shrinkage and depth of response on survival outcomes in patients with RAS wild-type metastatic colorectal cancer receiving treatment in three randomised panitumumab trials

Journal of Cancer Research and Clinical Oncology
Julien TaiebM Peeters

Abstract

To report exploratory analyses of early tumour shrinkage (ETS) and depth of response (DpR) in patients with RAS wild-type (WT) metastatic colorectal cancer (mCRC), receiving the first-line treatment in three randomised panitumumab trials. Data from the PRIME (NCT00364013), PEAK (NCT00819780) and PLANET (NCT00885885) studies were included. Median DpR, the proportion of patients achieving ETS ≥ 20% or ≥ 30% at week 8, and the impact of ETS and DpR (including by category) on outcome were analysed. Factors associated with ETS and DpR and the optimal ETS/DpR cut-off values for predicting improved overall survival (OS) were assessed. Overall, 505, 170 and 53 patients had RAS WT mCRC in PRIME, PEAK and PLANET, respectively. Patients receiving panitumumab had higher ETS rates (≥ 30%: PRIME 59% vs. 38%; PEAK 64% vs. 45%) and greater DpR (PRIME: 54% vs. 46%; PEAK: 65% vs. 46%) than those receiving treatment without panitumumab. In multiple regression analyses, panitumumab treatment, liver-only metastases and WT BRAF status were consistently associated with improved ETS and DpR outcomes. Irrespective of treatment, ETS and DpR were associated with improved progression-free survival, overall survival and resection rates; most resections occ...Continue Reading

References

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Citations

Nov 6, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik Paul ModestUNKNOWN XELAVIRI/AIO KRK0110 Investigators
Jul 11, 2019·International Journal of Clinical Oncology·Giuseppe A CollocaDomenico Guarneri
Aug 14, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R VeraE Aranda
Feb 10, 2019·Journal for Immunotherapy of Cancer·Meihua WangScot Ebbinghaus
Dec 5, 2018·World Journal of Clinical Cases·Feng XuChao-Liu Dai

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Methods Mentioned

BETA
surgical resection

Clinical Trials Mentioned

NCT00364013
NCT00819780
NCT00885885

Software Mentioned

PRIME
PLANET
RECIST
PEAK

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