Exploratory Analysis on Overall Survival after Either Surgery or Stereotactic Radiotherapy for Lung Oligometastases from Colorectal Cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
Andrea Riccardo FilippiE Ruffini

Abstract

Lung metastasectomy and, more recently, stereotactic body radiotherapy (SBRT), are frequently proposed to stage IV oligometastatic colorectal cancer (CRC) patients. In the absence of a randomised comparison between the two treatments, we aimed to retrospectively explore the effect on overall survival and progression-free survival (PFS) in a comparative cohort study. We included patients who consecutively underwent surgery (n = 142) or SBRT (n = 28) as first local therapy at the time of lung progression, between 2005 and 2012. Both overall survival and PFS functions according to treatment were calculated using the Kaplan-Meier method and compared using the Log-rank test. The effect of treatment on overall survival and PFS was estimated by Cox models using different adjustment methods. Patients receiving SBRT were older and were treated more recently, whereas the two cohorts were similar for most baseline prognostic factors. Overall survival at 1 and 2 years was 0.89 and 0.77 for SBRT and 0.96 and 0.82 for surgery (P = 0.134), respectively. Multivariable analyses did not highlight a clear treatment effect on overall survival (adjusted hazard ratioSBRT versus surgery = 1.71; 95% confidence interval 0.82-3.54; P = 0.149) and even s...Continue Reading

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Citations

Jun 11, 2019·Interactive Cardiovascular and Thoracic Surgery·Shuangjiang LiGuowei Che
May 11, 2018·Current Opinion in Oncology·Edouard MassautVincent Donckier
Mar 12, 2020·Annals of Surgical Treatment and Research·Young Il KimJin Cheon Kim
Nov 12, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Aman SharmaJoost Jan Nuyttens

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