Abstract
The rationale of this study was to investigate the feasibility of three-dimensional (3D) methods to analyze (18)F-fluoro-deoxy-glucose (FDG) uptake in children with anaplastic astrocytoma (AA) in a multi-institutional trial, to compare 3D and two-dimensional (2D) methods and explore data associations with progression-free survival (PFS). 3D tumor volumes from pretreatment MR images (fluid attenuation inversion recovery and postgadolinium) of children with recurrent AA on a phase I trial of imatinib mesylate were co-registered to FDG positron emission tomography (PET) images. PET data were normalized. Four metrics were defined: the maximum ratio (maximum pixel value within the 3D tumor volume, normalized), the total ratio (cumulative pixel values within the tumor volume, normalized) and tumor mean ratio (total pixel value divided by volume, normalized). 2D analysis methods were compared. Cox proportional hazards models were used to estimate the association between these methods and PFS. Strongest correlations between 2D and 3D methods were with analyses using postcontrast T1 images for volume of interest (VOI). The analyses suggest 3D maximum tumor and mean tumor ratios, whether normalized by gray matter or white matter, were as...Continue Reading
References
Jun 1, 1985·Journal of Neurosurgery·N J PatronasS M Larson
Aug 1, 1987·Radiology·G Di ChiroD J De Michele
Dec 1, 1982·Neurology·G Di ChiroA P Wolf
Apr 1, 1995·Radiology·D DelbekeR M Kessler
Sep 1, 1996·Neurosurgery·O De WitteS Goldman
Jul 1, 1997·Journal of Computer Assisted Tomography·J WestR P Woods
Jan 11, 2001·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·U SalmanW Phillips
Feb 24, 2001·Journal of Neuro-oncology·O De WitteS Goldman
Apr 12, 2003·Neuroimaging Clinics of North America·Terence Z WongR Edward Coleman
Oct 16, 2003·Journal of Neuro-oncology·M V PadmaJ C Mantil
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lise BorgwardtKjeld Schmiegelow
Jan 20, 2006·The British Journal of Radiology·P J Ell
Mar 15, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anthony F Shields
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jelle BarentszWim Mali
Feb 13, 2007·Neuro-oncology·Ian F PollackJames M Boyett
Citations
Nov 26, 2009·Pediatric Radiology·Sunhee KimAshok Panigrahy
Jan 15, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine A ZukotynskiTina Young Poussaint
Jul 3, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Virginie FringsRonald Boellaard
Oct 1, 2008·PET Clinics·Michael J Gelfand, Susan E Sharp
Nov 28, 2019·Cancers·Agostino ChiaravallotiOrazio Schillaci
Jul 30, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine ZukotynskiTina Y Poussaint
Jan 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lebriz UsluHeike E Daldrup-Link
Apr 1, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine A ZukotynskiTina Young Poussaint
Jun 27, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine A ZukotynskiTina Y Poussaint
Dec 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Reza ValiRuth Lim