Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the Pediatric Brain Tumor Consortium (PBTC).

European Journal of Nuclear Medicine and Molecular Imaging
Gethin WilliamsTina Young Poussaint

Abstract

The rationale of this study was to investigate the feasibility of three-dimensional (3D) methods to analyze (18)F-fluoro-deoxy-glucose (FDG) uptake in children with anaplastic astrocytoma (AA) in a multi-institutional trial, to compare 3D and two-dimensional (2D) methods and explore data associations with progression-free survival (PFS). 3D tumor volumes from pretreatment MR images (fluid attenuation inversion recovery and postgadolinium) of children with recurrent AA on a phase I trial of imatinib mesylate were co-registered to FDG positron emission tomography (PET) images. PET data were normalized. Four metrics were defined: the maximum ratio (maximum pixel value within the 3D tumor volume, normalized), the total ratio (cumulative pixel values within the tumor volume, normalized) and tumor mean ratio (total pixel value divided by volume, normalized). 2D analysis methods were compared. Cox proportional hazards models were used to estimate the association between these methods and PFS. Strongest correlations between 2D and 3D methods were with analyses using postcontrast T1 images for volume of interest (VOI). The analyses suggest 3D maximum tumor and mean tumor ratios, whether normalized by gray matter or white matter, were as...Continue Reading

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Citations

Nov 26, 2009·Pediatric Radiology·Sunhee KimAshok Panigrahy
Jan 15, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine A ZukotynskiTina Young Poussaint
Jul 3, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Virginie FringsRonald Boellaard
Oct 1, 2008·PET Clinics·Michael J Gelfand, Susan E Sharp
Nov 28, 2019·Cancers·Agostino ChiaravallotiOrazio Schillaci
Jul 30, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine ZukotynskiTina Y Poussaint
Jan 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lebriz UsluHeike E Daldrup-Link
Apr 1, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine A ZukotynskiTina Young Poussaint
Jun 27, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Katherine A ZukotynskiTina Y Poussaint
Dec 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Reza ValiRuth Lim

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