Exploratory study of the association of volumetric modulated arc therapy (VMAT) plan robustness with local failure in head and neck cancer

Journal of Applied Clinical Medical Physics
Wei LiuMartin Bues

Abstract

This work is to show which is more relevant to cause local failures (LFs) due to patient setup uncertainty between the planning target volume (PTV) underdosage and the potential target underdosage subject to patient setup uncertainties in head and neck (H&N) cancer treated with volumetric-modulated arc therapy (VMAT). Thirteen LFs in 10 H&N patients treated by VMAT were analyzed. Measures have been taken to minimize the chances of insufficient target delineation for these patients and the patients were clinically determined to have LF based on the PET/CT scan results by an experienced radiologist and then reviewed by a second experienced radiation oncologist. Two methods were used to identify the possible locations of LF due to underdosage: (a) examining the standard VMAT plan, in which the underdosed volume in the nominal dose distribution (UVN) was generated by subtracting the volumes receiving the prescription doses from PTVs, and (b) plan robustness analysis, in which in addition to the nominal dose distribution, six perturbed dose distributions were created by translating the CT iso-center in three cardinal directions by the PTV margin. The coldest dose distribution was represented by the minimum of the seven doses in each...Continue Reading

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Citations

Feb 26, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Gregory Robert Hopkins, Brett C Irvin
Apr 26, 2019·Physics in Medicine and Biology·Jong Min ParkJung-In Kim
Jul 2, 2019·Current Opinion in Ophthalmology·Sébastien Ruiters, Ilse Mombaerts
Oct 16, 2020·Journal of Applied Clinical Medical Physics·Hongying FengWei Liu

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Software Mentioned

Eclipse
VMAT

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