Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study

RMD Open
Maria-Antonietta D'AgostinoManuela Le Bars

Abstract

To explore whether changes in a composite (power Doppler/greyscale ultrasound (PDUS)) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, predict disease activity outcomes in rheumatoid arthritis (RA). Patients with RA who were methotrexate inadequate responders starting abatacept were evaluated. Individual joint PDUS scores were combined in the Global OMERACT-EULAR Synovitis Score (GLOESS) for metacarpophalangeal joints (MCPs) 2-5, all joints (22 paired) and a reduced (9 paired) joint set. The predictive value of changes in GLOESS at week 1-16 evaluations for clinical status and response (Disease Activity Score (DAS)28 (C reactive protein, CRP) <2.6; DAS28(CRP) ≤3.2; DAS28(CRP) ≥1.2 improvement) up to week 24, and correlations between DAS28 and GLOESS were assessed. Eighty-nine patients completed the 24-week treatment period. Changes in GLOESS (MCPs 2-5) from weeks 1 to 16 were unable to predict DAS28 outcomes up to week 24. However, significant improvements in GLOESS (MCPs 2-5) were observed at week 12 in patients with DAS28 ≥1.2 improvement at week 24 versus those who did not achieve that clinical response. In patients achieving DAS28 ≥1.2 improvement or DAS28 ≤3.2 at week 24, changes in GLOESS (22 and 9 p...Continue Reading

Citations

Oct 26, 2016·Joint, Bone, Spine : Revue Du Rhumatisme·Marine Forien, Sébastien Ottaviani
Dec 20, 2017·Clinical Rheumatology·Rosa Elda Barbosa-CobosJosé Moreno
Apr 14, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·George PentazosElias Siores
Dec 17, 2017·The Journal of Rheumatology·Mads Ammitzbøll-DanielsenLene Terslev
Jan 18, 2018·The Journal of Rheumatology·Pascal ZuffereyUNKNOWN SONAR Group and the SCQM Foundation
Mar 11, 2019·La Radiologia medica·Emilio FilippucciMarco Di Carlo
Feb 3, 2019·The Journal of Rheumatology·George A BruynUNKNOWN OMERACT Ultrasound Working Group
Apr 19, 2019·RMD Open·Alen ZabottiUNKNOWN OMERACT Ultrasound Task Force members
May 10, 2017·Clinical Rheumatology·Lucio Ventura-RíosUNKNOWN Grupo Mexicano de Ecografía Musculoesquelética AC (ECOMER)
Jun 17, 2020·The Journal of Rheumatology·Hélène VergneaultJérôme Avouac
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Feb 20, 2021·Arthritis & Rheumatology·Jérôme AvouacYannick Allanore

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Clinical Trials Mentioned

NCT00767325

Software Mentioned

GLOESS
APPRAISE

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