Exploring alternative rTMS strategies in non-responders to standard high frequency left-sided treatment: A switching study

Journal of Affective Disorders
Paul B FitzgeraldZafiris J Daskalakis

Abstract

High-frequency left-sided repetitive transcranial magnetic stimulation (rTMS) is now commonly used treatment for patients with depression. However, there are several other forms of rTMS (low-frequency right-sided and sequential bilateral rTMS) which have also been shown to be effective. No information has been systematically gathered on the likelihood of response to alternative forms of rTMS in patients who do not improve after an initial course of left-sided treatment. To evaluate whether there are differences in antidepressant response between switching to either low-frequency right sided or sequential bilateral stimulation or continuing high-frequency left-sided TMS following non-response to an initial course of high-frequency left-sided rTMS. 113 rTMS naïve patients were provided with an initial three-week course of high-frequency left-sided rTMS. Non-responders were then randomised to receive another three weeks of left-sided treatment (n = 21), right-sided low frequency stimulation (n = 18) or sequential bilateral rTMS (n = 20). Although there was an overall improvement in depressive symptoms in the randomised phase of the study, no significant differences in response was seen between the three treatment groups on Montgom...Continue Reading

Citations

Jul 14, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Paul B FitzgeraldZafiris J Daskalakis
Nov 27, 2020·Brain Stimulation·Davin K QuinnChristopher C Abbott
Jan 15, 2019·Psychiatry Research·F Andrew KozelGlenn Catalano

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