Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial

Chinese Journal of Integrative Medicine
Jia-Bo WangXiao-He Xiao

Abstract

To develop a new Chinese medicine (CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome (ARDS) in COVID-19 patients. A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized, controlled two-arm trial. The two arms of the trial consist of a control therapy (alpha interferon inhalation, 50 µg twice daily; and lopinavir/ritonavir, 400 and 100 mg twice daily, respectively) and a testing therapy (control therapy plus Keguan-1 19.4 g twice daily) by random number table at 1:1 ratio with 24 cases each group. After 2-week treatment, adverse events, time to fever resolution, ARDS development, and lung injury on newly diagnosed COVID-19 patients were assessed. An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events. Based on this result, the study was expanded to include a total of 48 participants (24 cases each arm). The results show that compared with the control arm, the testing arm exhibited a significant improvement in time to fever resolution (P=0.035), and a significant reduction in the development of ARDS (P=0.048). Keguan-...Continue Reading

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Citations

Oct 6, 2020·Chinese Journal of Integrative Medicine·Nan-Shan ZhongJing-Yi Liang
Feb 6, 2021·Chinese Journal of Integrative Medicine·Mariappan RajanAwanish Kumar
Jul 6, 2021·Journal of Clinical Epidemiology·Dongguang WangMike Clarke
Sep 30, 2021·Chinese Journal of Integrative Medicine·Muhammad AtifMuhammad Ikram Ullah

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