Exploring and Enhancing the Anti-Inflammatory Properties of Polymeric Formula

JPEN. Journal of Parenteral and Enteral Nutrition
Moftah AlhagamhmadS T Leach

Abstract

Exclusive enteral nutrition (EEN) therapy using a polymeric formula (PF) can substantially attenuate intestinal inflammation in Crohn's disease (CD) patients. However, the mechanism(s) by which EEN suppresses inflammation are not yet fully understood. The aims were to examine cellular mechanism(s) through which EEN may suppress inflammation and investigate potential pathways to enhance anti-inflammatory properties of EEN. Glutamine, arginine, vitamin D3, and α linolenic acid (ALA), present in PF, along with curcumin, were identified as immunoactive nutrient therapies. Tumor necrosis factor (TNF)-α-exposed HT-29 colonic epithelial cells were used to investigate the immunosuppressive activity of the nutrients by assessing their effect on cell viability, cell activity, chemokine response (interleukin-8 [IL-8]), nuclear factor (NF)-κB, P38 mitogen-activated protein kinase, IκB kinase (Iκκ), and nitric oxide (NO). Cellular viability and activity were maintained with all nutrient treatments. Glutamine, arginine, and vitamin D3, but not ALA, significantly attenuated IL-8 production. Glutamine and arginine led to phosphorylation blockade of the signaling components in NF-κB and P38 pathways, reduction in kinase activity, and enhancemen...Continue Reading

References

Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L Remy, J Marvaldi
Jun 9, 1995·The Journal of Biological Chemistry·H B PengJ K Liao
Oct 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A W Stadnyk
Feb 19, 1998·Alimentary Pharmacology & Therapeutics·D M McKayM H Perdue
Jan 15, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·E Den HondP Rutgeerts
Jan 12, 2000·Journal of Pediatric Gastroenterology and Nutrition·A K AkobengA G Thomas
Jul 23, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D MeisterS Ghosh
Sep 28, 2002·Critical Care Medicine·Frantisek NovakXiangyao Su
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jin-A KimYoung-Mi Lee
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Niki L ReynaertYvonne M W Janssen-Heininger
Sep 29, 2004·Free Radical Biology & Medicine·Ananda S PrasadFazlul H Sarkar
Aug 4, 2005·European Journal of Clinical Nutrition·J OckengaS C Bischoff
Nov 7, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carol LangPeter Zalewski
Aug 25, 2007·The Journal of Physiology·Ana VasilijevicBato Korac
Nov 30, 2007·Alimentary Pharmacology & Therapeutics·A S DayD A Lemberg
Apr 25, 2008·Journal of Agricultural and Food Chemistry·Chaiwat BoonkaewwanMrinalini C Rao
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun-Mi KoHern-Ku Lee
Jun 6, 2009·World Journal of Gastroenterology : WJG·Corina HartmanRaanan Shamir
Jan 27, 2010·The British Journal of Nutrition·Jenny EpsteinThomas T Macdonald
Nov 16, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Stanislaw KlekJan Kulig
Jul 26, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shunji HasegawaSusumu Furukawa
Dec 14, 2011·Biochimie·Céline LesueurCarole Brasse-Lagnel
Mar 9, 2012·Journal of Crohn's & Colitis·Imogen NicholsonWael El-Matary
Jun 16, 2012·Journal of Gastroenterology·Moftah H AlhagamhmadSteven T Leach
Feb 7, 2013·Current Opinion in Gastroenterology·Takayuki Yamamoto
Jan 3, 2014·Gastroenterology Research and Practice·S KansalA G Catto-Smith
Feb 26, 2014·Nature Reviews. Immunology·Lance W Peterson, David Artis
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alon LangShomron Ben-Horin

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Citations

Jan 13, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Moftah H Alhagamhmad
Nov 18, 2018·Journal of Digestive Diseases·Yi Quan ZhouYan Ping Wan
Aug 30, 2019·Current Opinion in Gastroenterology·Ron Shaoul, Andrew S Day
Sep 22, 2019·Nutrients·Simona Di CaroFarooq Rahman
Aug 3, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Amit Assa, Raanan Shamir
Apr 28, 2018·Nutrients·Tawnya Hansen, Donald R Duerksen
Jan 17, 2021·Nutrients·Charlotte M VerburgtJohan E Van Limbergen

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
electrophoresis
biopsies
nuclear translocation

Software Mentioned

GraphPad Prism

Related Concepts

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