Exploring and validating surrogate endpoints in colorectal cancer.

Lifetime Data Analysis
T BurzykowskiDan Sargent

Abstract

Sargent et al (J Clin Oncol 23: 8664-8670, 2005) concluded that 3-year disease-free survival (DFS) can be considered a valid surrogate (replacement) endpoint for 5-year overall survival (OS) in clinical trials of adjuvant chemotherapy for colorectal cancer. We address the question whether the conclusion holds for trials involving other classes of treatments than those considered by Sargent et al. Additionally, we assess if the 3-year cutpoint is an optimal one. To this aim, we investigate whether the results reported by Sargent et al. could have been used to predict treatment effects in three centrally randomized adjuvant colorectal cancer trials performed by the Japanese Foundation for Multidisciplinary Treatment for Cancer (JFMTC) (Sakamoto et al. J Clin Oncol 22:484-492, 2004). Our analysis supports the conclusion of Sargent et al. and shows that using DFS at 2 or 3 years would be the best option for the prediction of OS at 5 years.

References

Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Junichi SakamotoUNKNOWN Meta-Analysis Group in Cancer
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J SargentAimery De Gramont
Nov 4, 2006·Pharmaceutical Statistics·Tomasz Burzykowski, Marc Buyse

❮ Previous
Next ❯

Citations

Apr 25, 2009·International Journal of Clinical Oncology·Qian Shi, Daniel J Sargent
Jul 16, 2011·International Journal of Technology Assessment in Health Care·Russell J BowaterRichard J Lilford
Apr 7, 2010·Nature Reviews. Clinical Oncology·Marc BuyseAimery de Gramont
Sep 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N MethyF Bonnetain
Nov 12, 2009·Journal of the National Cancer Institute·Kristine R Broglio, Donald A Berry
Jun 29, 2011·Journal of the National Cancer Institute·Lawrence RubinsteinMalcolm A Smith
Oct 31, 2012·OncoTargets and Therapy·Beth SherrillConnie Chen
Jun 1, 2008·Expert Review of Pharmacoeconomics & Outcomes Research·Ariel Alonso, Geert Molenberghs
Jul 2, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A BhanguP Tekkis
Jun 7, 2014·Journal of Biopharmaceutical Statistics·Lindsay A RenfroDaniel J Sargent
Sep 21, 2019·JAMA Network Open·Tomasz BurzykowskiUNKNOWN Aide et Recherche en Cancerologie Digestive Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Marc BuysePascal Piedbois
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
T BurzykowskiPatrick Therasse
© 2021 Meta ULC. All rights reserved