Exploring antibiofilm potential of bacitracin against streptococcus mutans.

Microbial Pathogenesis
Sahar ZaidiAsad U Khan

Abstract

Bacitracin has well familiar effects on growth and colonization of bacteria but its antibiofilm action on majority of bacteria is still not studied. Bacitracin is a bactericidal antibiotic that primarily acts on Gram positive bacteria by obstructing the process of cell wall synthesis. In this study, we have investigated antibiofilm potential and the mechanism of bacitracin against a cariogenic bacteria 'Streptococcus mutans' which has not been reported so far. Bacitracin has been found to affect propensity of S. mutans to form biofilm. On treatment with sub-MIC concentration of bacitracin resulted in significant reduction in bifilm formation as evaluated by crystal violet and congo red assays. The architecture of S. mutans biofilm was observed by scanning electron microscopy which revealed astonishing phenotype of biofilm. Deficient biofilm was found to be composed of abnormally elongated cells. Transmission electron microscopy showed multiple septa formation in each cell of biofilm thereby indicating, cell division defect as the most probable cause of cell elongation. To elucidate the effect of bacitracin on molecular level, expression profiling of genes critically important for cell division and biofilm formation was performe...Continue Reading

References

Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·J M Andrews
Oct 7, 2003·Annual Review of Microbiology·Laura Romberg, Petra Anne Levin
Dec 4, 2003·Molecular Microbiology·Thorsten MascherJohn D Helmann
Oct 20, 2004·Molecular Microbiology·David S Weiss
Mar 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·G Siewert, J L Strominger
Jan 12, 2007·FEMS Microbiology Letters·David J LynchJeffrey A Banas
Aug 10, 2007·Nature·Curtis R Chong, David J Sullivan
Dec 18, 2007·FEMS Microbiology Reviews·Ahmed BouhssDominique Mengin-Lecreulx
Mar 26, 2008·Infection and Immunity·Paula J CrowleyL Jeannine Brady
Sep 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Costi D Sifri
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Thomas J SilhavySuzanne Walker
Dec 15, 2010·Protein & Cell·Chandrakala BasavannacharyaSanjib Bhakta
Mar 1, 2010·Nutrients·Sofia D ForsstenArthur C Ouwehand
Aug 2, 2012·Revue Scientifique Et Technique·K Bush
Oct 2, 2013·Nature Reviews. Drug Discovery·Thomas BjarnsholtNiels Høiby
Aug 27, 2014·Nature Reviews. Microbiology·Hilary Lappin-ScottPaul Stoodley
Dec 17, 2014·International Journal of Oral Science·Hong WuZhi-Jun Song
Jul 26, 2017·Frontiers in Microbiology·Muriel C F van TeeselingFelipe Cava
Apr 10, 2018·The Japanese Dental Science Review·Michiyo Matsumoto-Nakano

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