Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia.

Biological Research for Nursing
Victoria MenziesDebra E Lyon

Abstract

Fibromyalgia (FM) is a chronic noncommunicable disorder characterized by a constellation of symptoms that include fatigue, depression and chronic pain. FM affects 2%-8% of the U.S. population, 2% of the global population, with 61%-90% of FM diagnoses attributed to women. Key causal factors leading to the development and severity of FM-related symptoms have not yet been identified. The purpose of this article is to report relationships among identified metabolites and levels of fatigue, depression, pain severity, and pain interference in a sample of 20 women with FM. In this secondary analysis, we conducted global metabolomic analysis and examined the data for relationships of metabolite levels with self-reported symptoms of fatigue, depression, pain severity, and pain interference. Results revealed six metabolites (6-deoxy-hexose; pantothenic acid; ergothioneine; l-carnitine; n-acetylserotonin; butyrobetaine) and their associated metabolic pathways such as carnitine synthesis, lipid oxidation, tryptophan metabolism, beta-alanine metabolism and pantothenic and Coenzyme-A biosynthesis that were either positively or inversely related to pain severity, pain interference, or both. The preliminary data presented suggest that metaboli...Continue Reading

References

Aug 31, 2016·Proceedings of the National Academy of Sciences of the United States of America·Robert K NaviauxEric Gordon

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Citations

Feb 18, 2021·Pain and Therapy·Roberto CasaleAntonella Paladini
May 1, 2021·International Journal of Molecular Sciences·Rosalba SiracusaDaniela Impellizzeri
Sep 4, 2020·Journal of the American Society for Mass Spectrometry·Iqbal Mahmud, Timothy J Garrett

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Methods Mentioned

BETA
metabolomic profiling
metabolomics profiling

Software Mentioned

R
MetaboAnalyst

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