Exploring cardiac biophysical properties

Global Cardiology Science & Practice
Younss Ait MouPieter P de Tombe

Abstract

The heart is subject to multiple sources of stress. To maintain its normal function, and successfully overcome these stresses, heart muscle is equipped with fine-tuned regulatory mechanisms. Some of these mechanisms are inherent within the myocardium itself and are known as intrinsic mechanisms. Over a century ago, Otto Frank and Ernest Starling described an intrinsic mechanism by which the heart, even ex vivo, regulates its function on a beat-to-beat basis. According to this phenomenon, the higher the ventricular filling is, the bigger the stroke volume. Thus, the Frank-Starling law establishes a direct relationship between the diastolic and systolic function of the heart. To observe this biophysical phenomenon and to investigate it, technologic development has been a pre-requisite to scientific knowledge. It allowed for example to observe, at the cellular level, a Frank-Starling like mechanism and has been termed: Length Dependent Activation (LDA). In this review, we summarize some experimental systems that have been developed and are currently still in use to investigate cardiac biophysical properties from the whole heart down to the single myofibril. As a scientific support, investigation of the Frank-Starling mechanism wil...Continue Reading

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Citations

Jan 19, 2016·Global Cardiology Science & Practice·Yasmine Aguib, Jassim Al Suwaidi
Jan 26, 2018·Critical Care : the Official Journal of the Critical Care Forum·Maria Helena Calixto FernandesRoupen Hatzakorzian
Aug 2, 2018·International Journal of Molecular Sciences·Petr G Vikhorev, Natalia N Vikhoreva
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Immacolata BelvisoClotilde Castaldo
Dec 13, 2019·Cell & Bioscience·Alexandre Vallée, Yves Lecarpentier
Apr 17, 2020·Frontiers in Physiology·William W Muir, Robert L Hamlin

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Methods Mentioned

BETA
X-Ray
force measurement

Software Mentioned

Vassort
MyoTak

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