Exploring consequences of simulation design for apparent performance of methods of meta-analysis.

Statistical Methods in Medical Research
Elena KulinskayaIlyas Bakbergenuly

Abstract

Contemporary statistical publications rely on simulation to evaluate performance of new methods and compare them with established methods. In the context of random-effects meta-analysis of log-odds-ratios, we investigate how choices in generating data affect such conclusions. The choices we study include the overall log-odds-ratio, the distribution of probabilities in the control arm, and the distribution of study-level sample sizes. We retain the customary normal distribution of study-level effects. To examine the impact of the components of simulations, we assess the performance of the best available inverse-variance-weighted two-stage method, a two-stage method with constant sample-size-based weights, and two generalized linear mixed models. The results show no important differences between fixed and random sample sizes. In contrast, we found differences among data-generation models in estimation of heterogeneity variance and overall log-odds-ratio. This sensitivity to design poses challenges for use of simulation in choosing methods of meta-analysis.

References

Apr 16, 1999·Statistics in Medicine·R W PlattN Breslow
Dec 21, 2000·Statistics in Medicine·R M TurnerS G Thompson
Oct 11, 2002·Statistics in Medicine·Kurex Sidik, Jeffrey N Jonkman
Feb 8, 2006·Statistics in Medicine·Wolfgang Viechtbauer
Sep 7, 2006·Statistics in Medicine·Kurex Sidik, Jeffrey N Jonkman
Oct 22, 2010·Statistics in Medicine·Masayuki Henmi, John B Copas
Oct 30, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Sofia DiasNicky J Welton
May 9, 2013·Journal of Clinical Epidemiology·Ghada Abo-ZaidRichard David Riley
Mar 27, 2015·Statistics in Medicine·T D Stanley, Hristos Doucouliagos
Sep 4, 2015·Research Synthesis Methods·Areti Angeliki VeronikiGeorgia Salanti
Nov 18, 2015·BMC Medical Research Methodology·Christian RöverTim Friede
Jul 1, 2016·Research Synthesis Methods·Tim FriedeBeat Neuenschwander
Jan 27, 2017·Statistics in Medicine·Ilyas Bakbergenuly, Elena Kulinskaya
May 11, 2018·Statistical Methods in Medical Research·Kengo NagashimaToshi A Furukawa
Jul 6, 2018·BMC Medical Research Methodology·Ilyas Bakbergenuly, Elena Kulinskaya
Aug 2, 2018·Research Synthesis Methods·Dean LanganMark Simmonds
Mar 1, 2020·Research Synthesis Methods·Ilyas BakbergenulyElena Kulinskaya

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Citations

Jul 6, 2021·Statistics in Medicine·Brinley N ZabriskiePralay Senchaudhuri

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