Exploring dinoflagellate biology with high-throughput proteomics

Harmful Algae
David MorseSamuel C L Lo

Abstract

Dinoflagellates are notorious for their ability to form the harmful algal blooms known as "red tides," yet the mechanisms underlying bloom formation remain poorly understood. Despite recent advances in nucleic acid sequencing, which have generated transcriptomes from a wide range of species exposed to a variety of different conditions, measuring changes in RNA levels have not generally produced great insight into dinoflagellate cell biology or environmental physiology, nor do we have a thorough grasp on the molecular events underpinning bloom formation. Not only is the transcriptomic response of dinoflagellates to environmental change generally muted, but there is a markedly low degree of congruency between mRNA expression and protein expression in dinoflagellates. Herein we discuss the application of high-throughput proteomics to the study of dinoflagellate biology. By profiling the cellular protein complement (the proteome) instead of mRNA (the transcriptome), the biomolecular events that underlie the changes of phenotypes can be more readily evaluated, as proteins directly determine the structure and the function of the cell. Recent advances in proteomics have seen this technique become a high-throughput method that is now a...Continue Reading

Citations

Aug 28, 2019·Microorganisms·Yali BiWeiwen Zhang
Feb 9, 2020·Marine Drugs·Muhamad Afiq AkbarHamidun Bunawan
Aug 23, 2020·Microorganisms·Maëlle JaouannetChristine Coustau
Aug 30, 2019·Journal of Proteomics·Carlos FajardoFrancisco Javier Fernandez-Acero

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