Exploring environment-dependent effects of Pd nanostructures on reactive oxygen species (ROS) using electron spin resonance (ESR) technique: implications for biomedical applications

Physical Chemistry Chemical Physics : PCCP
Tao WenXiaochun Wu

Abstract

Recently, because of the great advances in tailoring their shape and structure, palladium nanoparticles (Pd NPs) have been receiving increasing attention in biomedical fields apart from their traditional application as industrial catalysts. When considering the potential uses of Pd NPs in biomedicine, their catalytic properties need to be evaluated under physiologically relevant conditions. In this article, we demonstrate that Pd nanostructures (NSs, both commercial Pd NPs and in-house-prepared Au@Pd nanorods) can induce O2 or ˙OH production depending on pH values in the presence of H2O2. We observed that O2 is produced under neutral and alkaline conditions but ˙OH under acidic conditions. We also found that Pd NSs can scavenge superoxide and singlet oxygen, which may provide protection in biological systems. On the other hand, their oxidase-like activity may accelerate the oxidation of ascorbic acid and thus may produce negative biological effects. The presented study will provide useful guidance for designing noble metal nanostructures with desired catalytic and biological properties in biomedical applications.

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Citations

Nov 9, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Gao-Juan CaoJun-Jie Yin
Dec 1, 2018·Beilstein Journal of Nanotechnology·Alexander RostekMatthias Epple
Jan 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiumei JiangJun-Jie Yin
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Jun 25, 2019·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Xiumei JiangJun-Jie Yin
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei SongXiaofeng Lu
Feb 12, 2021·Bioconjugate Chemistry·Ruiying ZhaoXiao-Dong Zhang
Nov 21, 2017·Journal of the American Chemical Society·Jun GuoZhiyong Tang

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