Exploring immune checkpoints as potential therapeutic targets in atherosclerosis

Cardiovascular Research
Pascal J H KustersTom T P Seijkens

Abstract

In the past decades, the inflammatory nature of atherosclerosis has been well-recognized and despite the development of therapeutic strategies targeted at its classical risk factors such as dyslipidemia and hypertension, atherosclerosis remains a major cause of morbidity and mortality. Additional strategies targeting the chronic inflammatory pathways underlying the development of atherosclerosis are therefore required. Interactions between different immune cells result in the secretion of inflammatory mediators, such as cytokines and chemokines, and fuel atherogenesis. Immune checkpoint proteins have a critical role in facilitating immune cell interactions and play an essential role in the development of atherosclerosis. Although the therapeutic potential of these molecules is well-recognized in clinical oncology, the use of immune checkpoint modulators in atherosclerosis is still limited to experimental models. Here, we review recent insights on the role of immune checkpoint proteins in atherosclerosis. Additionally, we explore the therapeutic potential and challenges of immune checkpoint modulating strategies in cardiovascular medicine and we discuss novel therapeutic approaches to target these proteins in atherosclerosis.

References

Jan 1, 1997·The Journal of Pathology·J J Boyle
Nov 25, 1998·Seminars in Immunology·D S Vinay, B S Kwon
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·T S LeeL Y Chau
Nov 5, 1999·Nature Medicine·E LutgensR A Flavell
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Feb 14, 2002·Trends in Cardiovascular Medicine·Esther Lutgens, Mat J A P Daemen
Feb 8, 2006·Nature Medicine·Hafid Ait-OufellaZiad Mallat
Sep 15, 2007·The Journal of Clinical Investigation·Israel GotsmanAndrew H Lichtman
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Ana LuqueJerzy Krupinski
Dec 6, 2008·Journal of Molecular and Cellular Cardiology·Jun LeeQiangsun Zheng
Feb 11, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Wonyoung KimByungsuk Kwon
May 12, 2009·Immunological Reviews·Roselynn Rodriguez-ManzanetDale T Umetsu
Jul 21, 2009·Seminars in Immunology·David EngelEsther Lutgens
Dec 5, 2009·Nature Reviews. Immunology·Ira Tabas
Dec 23, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Liu DongmingYang Ping
Feb 24, 2010·Circulation·Hyung Jun JeonGoo Taeg Oh
May 28, 2010·Journal of Innate Immunity·Ronald W van OlffenMartijn A Nolte
Jul 20, 2010·Immunological Reviews·Loise M FranciscoArlene H Sharpe
Mar 12, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·De-xiu BuAndrew H Lichtman
Mar 15, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jinchuan YanGuanghua Chen
Apr 20, 2011·Nature Reviews. Cardiology·Charlotte LahouteAlain Tedgui
Feb 23, 2012·Frontiers in Physiology·Andrew H Lichtman
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Apr 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margarite L TarrioAndrew H Lichtman
Oct 23, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Amanda C FoksGijs H M van Puijvelde
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
Aug 24, 2013·European Heart Journal·Seppo Ylä-HerttualaUNKNOWN ESC Working Group of Atherosclerosis and Vascular Biology
Aug 31, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Amanda C FoksGijs H M van Puijvelde
Jan 22, 2014·Nature Communications·Raphaël DuivenvoordenWillem J M Mulder
Feb 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Antonios ChatzigeorgiouEsther Lutgens

❮ Previous
Next ❯

Citations

Aug 4, 2018·Current Opinion in Lipidology·Tom T P Seijkens, Esther Lutgens
Jun 23, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Ellen Rouwet, Esther Lutgens
Nov 25, 2018·The Journal of Pathology·Suzanne Abm AartsEsther Lutgens
Feb 5, 2019·Cardiovascular Research·Jiun-Ruey HuJavid Moslehi
Apr 5, 2019·Cardiovascular Research·Asif J Iqbal
May 24, 2019·European Heart Journal·Esther LutgensChristian Weber
Jul 13, 2019·Cardiovascular Research·Meritxell NusAndrew Sage
Mar 10, 2020·Cardiovascular Research·Marta Czesnikiewicz-Guzik, Renata Górska
May 31, 2019·Scientific Reports·Hilman Zulkifli AminKen-Ichi Hirata
Jun 13, 2020·Journal of Leukocyte Biology·Lindsey E PadgettClaire E Olingy
Feb 18, 2020·Circulation Research·Ryszard NosalskiTomasz J Guzik
Mar 31, 2020·Journal of Cardiovascular Translational Research·Laura A BosmansTom T P Seijkens
Jun 26, 2020·Frontiers in Cardiovascular Medicine·Kikkie PoelsTom T P Seijkens
Feb 17, 2019·Nature Reviews. Cardiology·Karin H SimonsPaul H A Quax
Nov 8, 2019·Cardiovascular Research·Heather Y Small, Tomasz J Guzik
Jun 10, 2020·Current Oncology Reports·Arjun KhungerNikhil Agrawal
Mar 7, 2021·Cells·Timoteo MarchiniDennis Wolf
Sep 30, 2020·Cytokine & Growth Factor Reviews·Simone Cristina Soares BrandãoMasanori Aikawa
Sep 14, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jair BarAmir Onn
May 13, 2021·Circulation Research·Christina KassiteridiClaudia Monaco
Jun 26, 2021·Journal for Immunotherapy of Cancer·Kikkie PoelsTom T P Seijkens
Jul 6, 2021·JACC. Basic to Translational Science·Tanyaporn PattarabanjirdColeen McNamara
Jul 23, 2021·QJM : Monthly Journal of the Association of Physicians·Cecilia Assunta BonfiglioEsther Lutgens
Nov 16, 2021·International Reviews of Immunology·Azin AghamajidiNazanin Mojtabavi
Dec 24, 2021·Hämostaseologie·Timoteo MarchiniDennis Wolf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Shahzada Amir, Christoph J Binder
© 2022 Meta ULC. All rights reserved