Exploring interactions between force, repetition and posture on intervertebral disc height loss and bulging in isolated porcine cervical functional spinal units from sub-acute-failure magnitudes of cyclic compressive loading

Journal of Biomechanics
Chad E Gooyers, Jack P Callaghan

Abstract

Most in vitro studies are limited in the ability to partition intervertebral disc (IVD) height loss from total specimen height loss since the net changes in the actuator position of the materials testing system simply reflect net changes to functional spinal units (FSUs) used for testing. Three levels of peak compressive force, three cycle rates and two dynamic postural conditions were examined using a full-factorial design. Cyclic compressive force was applied using a time-varying waveform with synchronous flexion/extension for 5000 cycles. Surface scans from the anterior aspect of the IVD were recorded in a neutral and flexed posture before and after the cyclic loading protocol using a 3D laser scanner to characterise changes in IVD height loss and bulging. A significant three-way interaction (p=0.0092) between the magnitude of peak compressive force, cycle rate and degree of postural deviation was observed in cycle-varying specimen height loss data. A significant main effect of peak compressive force (p=0.0003) was also observed in IVD height loss calculated from the surface profiles of the IVD. The relative contribution of IVD height loss (measured on the anterior surface) to total specimen height loss across experimental c...Continue Reading

References

May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T R OxlandJ S Duranceau
Mar 1, 1987·Spine·M A AdamsW C Hutton
Jan 1, 1967·Acta Orthopaedica Scandinavica·J O Galante
Jun 21, 2001·Clinical Biomechanics·Karl H Wenger, John D Schlegel
Jan 29, 2003·Clinical Biomechanics·Rosemary E ThompsonMark J Pearcy
Jan 6, 2009·Clinical Biomechanics·Robert J Parkinson, Jack P Callaghan
Nov 26, 2009·Computer Methods in Biomechanics and Biomedical Engineering·Thomas ZanderAntonius Rohlmann
Jan 1, 1989·Clinical Biomechanics·P BrinckmannD Hilweg

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