Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy

Bioscience Reports
Paola M DantonioRicardo G Correa

Abstract

Although most melanoma cases may be treated by surgical intervention upon early diagnosis, a significant portion of patients can still be refractory, presenting low survival rates within 5 years after the discovery of the illness. As a hallmark, melanomas are highly prone to evolve into metastatic sites. Moreover, melanoma tumors are highly resistant to most available drug therapies and their incidence have increased over the years, therefore leading to public health concerns about the development of novel therapies. Therefore, researches are getting deeper in unveiling the mechanisms by which melanoma initiation can be triggered and sustained. In this context, important progress has been achieved regarding the roles and the impact of cellular signaling pathways in melanoma. This knowledge has provided tools for the development of therapies based on the intervention of signal(s) promoted by these cascades. In this review, we summarize the importance of major signaling pathways (mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)-Akt, Wnt, nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB), Janus kinase (JAK)-signal transducer and activator of transcription (STAT), transforming growth factor ...Continue Reading

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Citations

Mar 7, 2019·Bioscience Reports·Fernando J VellosoRicardo G Correa
May 21, 2020·FEBS Open Bio·Lisa M HillenVéronique Winnepenninckx
May 15, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nisha S RamaniCarlos A Torres-Cabala
Jun 6, 2019·Archives of Dermatological Research·Abdullah Alyoussef, Medhat Taha
Nov 18, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Letizia PorcelliAmalia Azzariti

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Methods Mentioned

BETA
GTPases
nucleotide exchange
xenograft
ubiquitination
nuclear translocation
sumoylation

Clinical Trials Mentioned

NCT02967692
NCT01657591
NCT01909453
NCT02807844
NCT02404441
NCT00022464
NCT03131908
NCT01351103
NCT02816021
NCT02646748

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