Exploring new frontiers of nitrogenase structure and mechanism

Current Opinion in Chemical Biology
John W Peters, Robert K Szilagyi

Abstract

The mechanism of the complex enzyme nitrogenase has long been one of the most challenging problems in bioinorganic chemistry. The complexity of the metal centers of nitrogenase has stretched the boundaries of biochemical, physical and computational tools for providing insights into its structure and chemical function. Recently, there have been several key advances in crystallography and spectroscopy that have impacted the way the nitrogenase mechanism is approached. These advances have opened new frontiers in nitrogenase research, which has started to reveal novel details about the molecular structure, substrate binding and reduction. Here, we discuss these recent advances and their implications on the future of nitrogenase research.

References

Feb 7, 2001·The Journal of Biological Chemistry·J ChristiansenD R Dean
Nov 7, 1996·Chemical Reviews·James B. Howard, Douglas C. Rees
Feb 6, 2003·Journal of the American Chemical Society·Berit Hinnemann, Jens K Nørskov
Mar 5, 2003·Chemical Communications : Chem Comm·Ian Dance
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sonny C Lee, Richard H Holm
Apr 3, 2003·Journal of the American Chemical Society·Uwe BergmannStephen P Cramer
May 8, 2003·Journal of the American Chemical Society·Hong-In LeeBrian M Hoffman
Jul 5, 2003·Science·Dmitry V Yandulov, Richard R Schrock
Dec 18, 2003·Journal of the American Chemical Society·Johannes SchimplPeter E Blöchl
Feb 11, 2004·Biochemistry·Lance C SeefeldtDennis R Dean
Feb 26, 2004·Journal of the American Chemical Society·Uwe HuniarDimitri Coucouvanis
Mar 3, 2004·The Journal of Biological Chemistry·Patricia C Dos SantosDennis R Dean
Mar 25, 2004·Journal of the American Chemical Society·Berit Hinnemann, Jens K Nørskov
Oct 7, 2004·The Journal of Biological Chemistry·Brett M BarneyLance C Seefeldt
Jan 5, 2005·Journal of Bacteriology·Luis M Rubio, Paul W Ludden
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yilin HuMarkus W Ribbe
Mar 16, 2005·Accounts of Chemical Research·Patricia C Dos SantosDennis R Dean
Jun 1, 2005·Biochemistry·Brett M BarneyLance C Seefeldt
Jun 21, 2005·Inorganic Chemistry·Johannes Kästner, Peter E Blöchl
Jul 14, 2005·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Johannes Kästner, Peter E Blöchl
Sep 15, 2005·Journal of the American Chemical Society·Tran-Chin YangBrian M Hoffman
Sep 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yilin HuMarkus W Ribbe
Oct 19, 2005·The Journal of Chemical Physics·Johannes KästnerPeter E Blöchl
Oct 27, 2005·Journal of the American Chemical Society·Brett M BarneyLance C Seefeldt

❮ Previous
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Citations

Aug 13, 2013·Journal of Molecular Evolution·Gabriela SotoNicolás Daniel Ayub
May 3, 2008·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Matthew C F WanderMartin A A Schoonen
May 7, 2011·Inorganic Chemistry·Travis V Harris, Robert K Szilagyi
May 18, 2011·Journal of the American Chemical Society·Ayumi TakaokaJonas C Peters
Apr 30, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Li CheTimothy K Minton
Mar 12, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Yilin HuMarkus W Ribbe
Jul 5, 2011·Journal of Bacteriology·Trinity L HamiltonJohn W Peters
Nov 6, 2008·Annual Review of Genetics·Katherine E GibsonGraham C Walker
Aug 20, 2015·International Journal of Molecular Sciences·Bargaz AdnaneCarlsson Georg
Jan 25, 2012·Biochimica Et Biophysica Acta·Benjamin R DuffusJoan B Broderick
Mar 26, 2011·Bioresource Technology·Dong-Hoon Kim, Mi-Sun Kim
Sep 17, 2015·Journal of Molecular Evolution·Cecilia PascuanNicolas Daniel Ayub
Jan 31, 2008·Biochemical and Biophysical Research Communications·Surobhi LahiriNara Gavini
Oct 28, 2015·Journal of the American Chemical Society·Lei WangLiang Deng
Sep 15, 2015·Physical Chemistry Chemical Physics : PCCP·J B VarleyJ K Nørskov
May 1, 2011·European Journal of Inorganic Chemistry·Lifen YanStephen P Cramer
Jan 5, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yilin HuMarkus W Ribbe
Oct 11, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Haruki YamamotoYuichi Fuita
Feb 13, 2009·Chembiochem : a European Journal of Chemical Biology·Olaf Kühl
Dec 6, 2019·Chembiochem : a European Journal of Chemical Biology·Ian Dance
Mar 29, 2014·Health·Rebecca Dimond
Nov 16, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Heejune Park, Giovanni Meloni
Jul 16, 2011·Angewandte Chemie·Deidra L Gerlach, Nicolai Lehnert
Mar 17, 2020·Chemical Reviews·Lance C SeefeldtBrian M Hoffman
Apr 3, 2020·Chemical Reviews·Casey Van StappenSerena DeBeer
Mar 5, 2008·Biochemistry·Yilin HuMarkus W Ribbe
Jun 18, 2010·Inorganic Chemistry·Christopher R SharpSonny C Lee

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