Exploring pathways for sustained melanogenesis in facial melasma: an immunofluorescence study

International Journal of Cosmetic Science
A C C EspósitoHélio Amante Miot

Abstract

The physiopathology of epidermal hypermelanization in melasma is not completely understood. Several cytokines and growth factors are increased in skin with melasma, nevertheless, nor the pathways involved in the increased αMSH expression have been adequately evaluated, nor a model for sustained focal melanogenesis is available. To explore stimulatory pathways for epidermal pigmentation in facial melasma related to αMSH: those linked to ultraviolet radiation, oxidative stress, inflammation, neural crest pigmentation cell differentiation and antagonism of αMSH. Paired skin biopsies (3 mm) from 26 women with facial melasma and from normal adjacent skin (<2 cm far) were processed for immunofluorescence with markers for p53, p38, αMSH, MC1R, Melan-A, IL-1α, COX2, Wnt1, WIF-1 and ASIP. The fluorescence intensity in the skin from melasma was higher for MC1R, αMSH at epidermis as at melanocytes (P < 0.05). There were no differences between the sites in epidermal protein expression of COX2, IL-1α, p53, WIF-1 and ASIP (P > 0.1). P53 was expressed only in epidermis, without difference between sites (P = 0.92). WNT1 was remarkable in the epidermis of melasma (P < 0.01), but not in dermis. Positive p38 cells were prominent in the upper derm...Continue Reading

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Citations

Aug 31, 2020·International Journal of Dermatology·Paula Basso LimaHélio Amante Miot
Apr 8, 2019·International Journal of Cosmetic Science·R SchützD Imfeld
Sep 19, 2019·Archives of Dermatological Research·Ana Cláudia Cavalcante EspósitoHélio Amante Miot
Nov 17, 2019·Ageing Research Reviews·Barbara Bellei, Mauro Picardo
Aug 1, 2020·Mechanisms of Ageing and Development·Ines MarticMaria Cavinato
Feb 28, 2021·Archives of Dermatological Research·Ana Cláudia Cavalcante EspósitoHélio Amante Miot
Apr 5, 2021·Anais Brasileiros De Dermatologia·Ana Cláudia Cavalcante EspósitoHélio Amante Miot
May 1, 2021·International Journal of Molecular Sciences·Young In LeeTae-Gyun Kim
May 29, 2021·Pigment Cell & Melanoma Research·Hee Young KangMauro Picardo

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