Exploring patient- and physician-related factors preventing breast cancer patients from guideline-adherent adjuvant chemotherapy-results from the prospective multi-center study BRENDA II

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Lukas SchwentnerSusanne Singer

Abstract

This study examined which patient- and physician-related factors influence guideline violations in adjuvant chemotherapy. In a prospective multi-center cohort study, patients with primary breast cancer were sampled consecutively over a period of four years (2009-2012). Patients completed a questionnaire prior to surgery and prior to adjuvant therapy. This questionnaire assessed health-related quality of life (QoL) using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, psychiatric co-morbidity with the Patient Health Questionnaire (PHQ), demographic characteristics (age, education), and the intensity of fear for chemotherapy. After surgery, a multi-professional team discussed recommendation for adjuvant chemotherapy, and this decision was documented in a database together with the indication for chemotherapy according to the German S3 guideline. This multi-professional team was blinded to that algorithm-based decision. Six months later, it was documented whether the patient had received adjuvant chemotherapy or not. Altogether, 857 patients were included in the study. In 391 of these patients, the tumor board (TB) decided to recommend chemotherapy. The most important reasons for not recommending ch...Continue Reading

References

Jan 1, 1990·Journal of General Internal Medicine·C E LermanH G Wolfson
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Schwarz, A Hinz
Aug 4, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicole Hébert-CroteauGinette Martin
Aug 7, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN 10th St. Gallen conference
Oct 15, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K HanckeR Kreienberg
May 25, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer Y WoRinaa S Punglia
Jul 12, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R WoltersA Wöckel
Sep 29, 2011·The Breast : Official Journal of the European Society of Mastology·Lukas SchwentnerAchim Wöckel
Oct 19, 2011·European Journal of Cancer Care·M Banning
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alfred I NeugutDawn L Hershman
Jul 23, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Paula A van LuijtUNKNOWN National Evaluation Team for Breast Cancer Screening in Netherlands Study Group (NETB)
Feb 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WöckelUNKNOWN BRENDA study group
Dec 18, 2014·The Breast : Official Journal of the European Society of Mastology·Christoph KowalskiSimone Wesselmann
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WöckelUNKNOWN BRENDA study group

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Citations

Nov 17, 2017·Health Information Science and Systems·Dennis AndrzejewskiEberhard Beck
Sep 12, 2019·Asia-Pacific Journal of Clinical Oncology·Amali SamarasinghePeter Willsher
May 8, 2020·Breast Cancer Research and Treatment·Ena Niño de GuzmánIgnacio Ricci-Cabello

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