Exploring polymorphisms and effects of candidate genes on milk fat quality in dairy sheep

Journal of Dairy Science
A CrisàB Moioli

Abstract

The aim of the present study was to investigate the genetic control of the fatty acid (FA) composition in milk from 3 breeds of sheep: Altamurana, Gentile di Puglia, and Sarda. Single nucleotide polymorphisms within genes, encoding enzymes putatively involved in the synthesis and metabolism of milk fat, were selected for analysis, and the allele substitution effects were determined for 16 genes, which were polymorphic in the 3 sheep breeds, upon the milk fat composition. Four genes (alpha-1-antichymotrypsin-2; diacylglycerol O-acyltransferase homolog-2; propionyl Coenzyme A carboxylase, beta polypeptide; and insulin-like growth factor-I) play a role in the desaturation of stearic FA into polyunsaturated fatty acids. Furthermore, 2 genes (growth hormone receptor and zona pellucida glycoprotein-2) affect the variability of the total fat content in addition to the butyric and stearic FA profile, and the fatty acid synthetase gene has an influence on the medium-chain FA. Milk FA profiles play an important role in dairy sheep farming because they have a large effect on cheese characteristics and also because sheep milk may be marketed as a source of nutraceuticals because it contains higher levels of conjugated linoleic acid than mi...Continue Reading

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Citations

Mar 16, 2013·Animal Genetics·B MoioliF Napolitano
Jun 18, 2015·PloS One·Huihua WangLixin Du
Feb 22, 2017·Animal : an International Journal of Animal Bioscience·B MoioliL Buttazzoni
Nov 26, 2016·BMC Veterinary Research·Alessandra CrisàBianca Moioli
Feb 6, 2020·The Journal of Dairy Research·Simoni SymeouDespoina Miltiadou
Nov 6, 2020·Cell and Tissue Research·Bala Krishnan BinsilaRaghavendra Bhatta
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Michaela BrzákováZuzana Sztankóová
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Michele PazzolaMaria Luisa Dettori

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