Exploring Sphingolipid Implications in Neurodegeneration

Frontiers in Neurology
Alice Alessenko, Elisabetta Albi

Abstract

Over the past decade, it was found that relatively simple sphingolipids, such as ceramide, sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in neuronal functions by regulating rates of neuronal growth and differentiation. Homeostasis of membrane sphingolipids in neurons and myelin is essential to prevent the loss of synaptic plasticity, cell death and neurodegeneration. In our review we summarize data about significant brain cell alterations of sphingolipids in different neurodegenerative diseases such as Alzheimer's disease, Parkinson disease, Amyotrophic Lateral Sclerosis, Gaucher's, Farber's diseases, etc. We reported results obtained in brain tissue from both animals in which diseases were induced and humans in autopsy samples. Moreover, attention was paid on sphingolipids in biofluids, liquor and blood, from patients. In Alzheimer's disease sphingolipids are involved in the processing and aggregation of β-amyloid and in the transmission of the cytotoxic signal β-amyloid and TNFα-induced. Recently, the gangliosides metabolism in transgenic animals and the relationship between blood sphingolipids changes and cognitive impairment in Alzheimer's disease patients have been intensively studied. Num...Continue Reading

References

Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Jul 1, 1985·Annals of Neurology·M M RapportH Bartfeld
Feb 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·R O BradyD S Fredrickson
Oct 1, 1996·International Psychogeriatrics·C G GottfriesL Svennerholm
May 1, 1997·Biochemistry and Molecular Biology International·K Tamiya-KoizumiS Yoshida
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C ZhangI D Duncan
Oct 28, 1999·Acta Neurologica Scandinavica·T EkegrenS M Aquilonius
Sep 22, 2001·Neurochemical Research·J W PettegrewR J McClure
Jan 17, 2002·The Journal of Biological Chemistry·Radhia MahfoudJacques Fantini
Jun 5, 2003·Bioorganic & Medicinal Chemistry Letters·Minoru TaguchiTakeo Kobori
Feb 28, 2004·Expert Reviews in Molecular Medicine·Jacques FantiniNouara Yahi
Jul 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Doris L FortinRobert H Edwards
Nov 3, 2004·Biology of the Cell·E Albi, M P Viola Magni
Feb 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Clifford W Shults
Aug 16, 2006·Neuro-degenerative Diseases·P Van DammeL Van Den Bosch
Oct 27, 2006·Biochimica Et Biophysica Acta·Jae-Ho Park, Edward H Schuchman
Apr 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christian S LobsigerDon W Cleveland
Jul 3, 2007·Pediatric Rheumatology Online Journal·Karoline EhlertJosef Vormoor
Sep 25, 2007·Neurobiology of Aging·Veera Venkata Ratnam BandaruNorman J Haughey
Dec 18, 2007·Journal of Neurochemistry·Je-Seong WonInderjit Singh
Dec 14, 2007·Biochimica Et Biophysica Acta·Subroto Chatterjee, Ambarish Pandey
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Mar 14, 2008·Human Mutation·Kathleen S HruskaEllen Sidransky
Jun 13, 2008·Neurobiology of Aging·Xingxuan HeEdward H Schuchman
Jan 17, 2009·Journal of the Neurological Sciences·Arundhati JanaKalipada Pahan
Jul 18, 2009·International Review of Neurobiology·Jin-Ichi Inokuchi
Sep 1, 2009·Biochimica Et Biophysica Acta·Ping ShiHaining Zhu
Oct 23, 2009·The New England Journal of Medicine·E SidranskyS G Ziegler
Jan 12, 2010·Journal of Neuroimmunology·Nguyen Thi XuanFlorian Lang
Mar 23, 2010·Biochimica Et Biophysica Acta·Kulandaivelu S Vetrivel, Gopal Thinakaran
May 11, 2010·Biochimica Et Biophysica Acta·Norman J HaugheyMark P Mattson
May 27, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Johannes KornhuberErich Gulbins
Jun 24, 2010·Neuromolecular Medicine·Michelle M Mielke, Constantine G Lyketsos

❮ Previous
Next ❯

Citations

Feb 14, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E I GusevM V Ugryumov
Dec 16, 2020·Journal of Translational Medicine·Michele Dei CasElisabetta Albi
Mar 2, 2021·Neural Regeneration Research·Elisabetta Albi, Alice V Alessenko
Jul 3, 2021·Biomolecules·Antía CustodiaAlberto Ouro
Aug 22, 2021·Nature Reviews. Drug Discovery·Thomas Bieber
Sep 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·François G C BlotMartijn Schonewille
Dec 9, 2021·Current Opinion in Lipidology·Laura M I LoftHéléne T Cronjé
Jan 6, 2022·The Journal of Clinical Endocrinology and Metabolism·Lars LindTove Fall

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Software Mentioned

SphLs

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

Annual Review of Biochemistry
W Stoffel
Journal of Alzheimer's Disease : JAD
Pilar Martinez Martinez, Michelle M Mielke
© 2022 Meta ULC. All rights reserved